Dr. Kent Berridge
speaker
525 appearances
1 recordings
1 series
first heard Aug 2026
last heard 4 Aug
Dr. Kent Berridge’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Aug 2026 with 1.
Appearances
But they don't want them.
They're not engaging.
They're not worth pursuing in the view of this person.
It's sort of a suppression of the wanting system.
And so new words to replace anhedonia, words like avolition, are sometimes being applied to those patients, a loss of will, a loss of wanting, to kind of say.
And the last thing, which kind of came as a surprise to me, but I think it's very interesting, is this wanting system, the incentive salience,
it can also overlap with a certain kind of fearful anxiety salience.
And when people are given, say, with schizophrenia, they're prescribed potent antipsychotic drugs that block dopamine D2 receptors.
Sometimes they block serotonin receptors too, but they all block the dopamine D2 receptors.
Sometimes this is given to kind of reduce paranoia.
And the intensity of that sort of
or something grabs your attention and it's a threat, and you weave it into the delusion that the police are following you, that someone's out to get you, something of that sort.
the dopamine wanting system has a kind of aversive, fearful salience mode that's distinguishable from its incentive salience mode, but it can flip a little bit back and forth.
People who take an amphetamine, you know, for the euphoric effects of that, but they can flip into amphetamine psychosis and which can involve paranoia.
So this is something, it's a sort of double dual face of the dopamine motivational salience system.
We don't quite understand fully how it's flipping, but it's fascinating that it can, and we'd love to understand that better.
Well, I'm on the internet here.
I'm here at the University of Michigan with an email address at the University of Michigan.
I'm not a clinician.
I'm not qualified to give any kind of clinical advice at all.
Showing 501–520 of 525 · page 26 of 27
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