Dr. Kent Berridge
speaker
525 appearances
1 recordings
1 series
first heard Aug 2026
last heard 4 Aug
Dr. Kent Berridge’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Aug 2026 with 1.
Appearances
The big champion of it was Roy Wise, who was an excellent neuroscientist in Montreal at that time.
And he had many experiments that would show they were animal experiments.
What he would do is he would block dopamine with a dopamine suppressing drug, an antipsychotic drug that blocks dopamine receptors.
And he would find that rats who had been working for food reward or sex reward or drug reward or brain stimulation electrode reward, which is a reward that rats will work for, any of these rewards, once they had this dopamine blockade, they gradually abandoned those rewards as though the pleasure of the rewards had drained out of them and they were no longer pleasant.
He called this extinction mimicry because it's what happens.
It looked like what happens, this gradual decay.
If you simply just stopped giving them the reward, they gradually cease working.
Well, they relapse.
That's right.
So if you take them home for the weekend, then bring them back next week and give them a chance, then they do relapse.
That's right.
They'll start working again.
But if you each time give them the dopamine blockade, gradually they will cease to relapse.
They will abandon these kinds of things.
So even this he called anhedonia, that is the lack of pleasure.
The dopamine blockade was producing the lack of pleasure.
And if dopamine blockade takes away the pleasure, it meant that dopamine itself was causing the pleasure.
This was the basis for the hypothesis.
He had clever experiments that kind of ruled out a few alternative interpretations.
And I believed it.
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