Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · 2 Jul 2026 podcast

Whereas if you're on testosterone therapy, then you're going to have a steady state.

So your testosterone level is going to be pretty much the same even in the evening.

So this is when you really have to be

at least well-versed in every organ system, not just the genital system.

You need to have dermatology prowess.

Acne is a very common change.

Lots of different skin pathologies or even bruising can be related to hormone replacement.

Hair loss is very common to see as well.

Mental status changes.

Occasionally it even induces a manic or a bipolar episode because testosterone is also dopaminergic.

And then cardiovascularly, not just in the heart, but also concerns for like microvascular ischemic disease,

ferritin buildup because the estrogen also increases, and then fertility concerns as well, and lipid concerns too.

So you really have to be, you know, hematologist, dermatologist, cardiologist, lipidologist, the whole nine yards.

Correct.

And if your physician that is managing or prescribing your testosterone therapy or your HRT is not well-versed in these systems, you would want him or her to be part of an interdisciplinary team where they have other experts that can monitor those systems.

It will increase testosterone in a dose-dependent manner, but it has many other pharmacodynamic effects, which is the effect of the drug on the body other than its effect on the hypothalamus and the pituitary.

So in the hypothalamus and the pituitary, it does what's called negative feedback inhibition, or it blocks the oxygen of estrogen.

So it crowds out estrogen from the estrogen receptor on the hypothalamus and the pituitary.

The main rationale behind taking a CIRM is as a very temporary measure that is not going to suppress pituitary or hypothalamic function if your testosterone is just so drastically low that it is unlikely to recover anyway.

So most of the time it is not clinically useful and CIRM should not be prescribed very often, certainly not as long-term testosterone replacement or testosterone optimization in most individuals.

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