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Dr. Kyle Gillett

๐Ÿ‘ค Speaker
308 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So testosterone is not going to cause a prostate cancer.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

However, normal aging causes prostate cancer and testosterone will grow your prostate cancer.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So if you're a 80-year-old male and you have an autopsy, then there's at least a 50% chance that you have a prostate cancer.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

If you're 90 or 100 years old, there's at least a 90% chance.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So for humans with a prostate, it's only a matter of time until you get a prostate cancer.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So that begs the question, do you want to take something that's going to grow it for sure once you have it?

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So it's an individual assessment.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

With aging, you know, fast aging is abnormal.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Very slow aging is normal.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

There's a fine line to walk between those two.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

The way I describe it is the dopamine wave pool.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So if you're increasing your dopamine too much, you're going to overflow, and then you're going to have that wave crash too much.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So you want to have nice, even waves that are not going too far above the pool of dopamine, and prolactin will follow.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So prolactin and estrogen are quite close cousins.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Estrogen upregulates a gene called the PRL gene or prolactin gene that directly increases prolactin synthesis.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So prolactin is going to also inhibit the release of testosterone from the pituitary.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So if you're using a dopamine agonist, then you're going to help decrease the prolactin producing cells.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

So if someone's concerned about dopamine, or maybe they have a slightly higher prolactin, then they eliminate things that could be increasing that prolactin.

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Such as?

Huberman Lab
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Casein or gluten, which are mu opioid receptor agonists or any mu opioid receptor agonist in the gut.