Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · 2 Jul 2026 podcast

That's a hormone that binds to the latex cell, to the LH receptor, kind of like HCG does.

And it will increase the release of testosterone.

There is one study, and this is a rat study, but you can equate the dose of toxicity in rats and humans.

They did not give these rats any antioxidants, but it increases a couple different pro-inflammatory markers.

One is GGT, or gamma-glutamyl transferase, comes from both the testes and the liver, and one is alkaline phosphatase, also known as ALKFOS, again, coming from both areas.

There are several different ways that you can attenuate this increase, and you can also just check to see if you have increased.

in the rat dose that equates with humans that had no effect, so the safe dose, was an average of 300 milligrams a day.

And often, even if there is toxicity in rats, there is not toxicity in humans, so it's not directly equitable.

But to be safe,

Another regimen that I have people take is 600 milligrams every other day or 600 milligrams three times a week, often Monday, Wednesday, Friday.

Some of this depends on the SHBG and free testosterone as well.

So if that same individual had a very high SHBG, which again is the binding protein that binds up the testosterone and all androgens and estrogens, if it is extremely high and they have a free testosterone of two,

then they might need a different dose because they need enough testosterone in order to have a normal eugonadal free testosterone.

But a general normal dosing range, especially for someone starting, is around 100 to 120 milligrams divided over the course of a week, usually either every other day or three times a week, occasionally twice a week.

Many people with SHBG a bit higher can get away pretty easily with twice a week.

This is assuming that the ester is cipionate or enanthate.

And I would consider this like a physiologic eugonadal dose.

For many people, even 200 milligrams a week is far above the reference range.

All of this is said with the caveat that testosterone is normally released in a pulsatile manner.

So it's high in the morning, low in the evening.

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