Dr. Kyle Gillett

If you have infertility, so if you're under the age of 35 and you've been trying for more than a year, or if you're over the age of 35 and you've been trying for more than six months, then that can also be, it's a very common presenting complaint when somebody presents with PCOS.

If they're very strong on the insulin resistance spectrum, then optimizing their body composition, decreasing their body fat, and treating that metabolic syndrome can help.

So a lot of people ask, well, does everybody that's on, like, does everybody need to be on metformin that has PCOS?

Not necessarily, but metformin is one of the tools that can help with insulin sensitization.

Other tools that can help are inositol.

So myoinositol is an insulin sensitizer.

Its cousin, D-chiral inositol, is a weak antiandrogen.

A lot of types of inositol have both of those in it.

So depending on if you're a female or a male and you're on inositol, the type of inositol does matter.

Cannabinoids itself, whether it's THC or CBD, are not going to reduce testosterone by themselves.

If it's smoked marijuana, then it's very likely to increase your aromatase, which increases your estrogen.

and it's aromatizing from testosterone.

So that is going to decrease testosterone.

When you have an increased estrogen, like estradiol, that's gonna work on your pituitary to make less hormones that cause the release of testosterone.

So you're gonna have less LH and less FSH.

So it's almost kind of like, opiates are well known to opiate agonists.

they're going to decrease LH and FSH and subsequently testosterone.

Smoked marijuana will as well.

As far as alcohol, high alcohol will decrease testosterone as will any very potent GABA agonist, whether it's a barbiturate or a benzodiazepine or a non-benzo or alcohol.

they're definitely going to.