Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · 2 Jul 2026 podcast

They can be shunted off to testosterone or estrogens or progestogens quite easily as well.

but Tomcat helps with the conversion of multiple key steps where you synthesize testosterone.

Another, think of it as like a coenzyme or a cofactor, an upregulator of these steps is insulin and IGF-1.

So a good rule of thumb is if you are not expecting as much growth hormone, insulin, and IGF-1, for example, lower carb diets, caloric deficits, you're trying to cut body fat or body weight, then Tomcat is going to be theoretically especially powerful.

anywhere from 300 to 1,200 milligrams a day.

With Tomcat, you need to be careful with the standardization because if you're thinking about a general Tomcat supplement, which is by far the most well-studied, then you're looking at the uricominone content, which is a plant compound that is likely the main active pharmacologic effect.

So that's the compound that's having the effect on the body.

And if you standardize the uricomonone very, very high, then theoretically you're having more effect at a lower dose.

Tonkat can also slightly increase DHEA.

And if you have a very high SHBG, again, that's the protein that binds up your androgens and estrogens, an extremely important protein.

The higher your SHBG, the more it helps decrease it.

So they've studied Tonkat in populations with very normal SHBGs, and it does nothing for SHBG.

Yes, it'll increase their total and free testosterone.

We can talk about Fidoja next.

Fidoja's interesting because it's a genus of plants.

Fidoja agrestis is one of them.

There's many others that are very interesting.

That species is likely the most well-studied, and it will increase LH.

So I would not consider it an LH memetic, so it doesn't really mimic it.

but it increases the release of luteinizing hormone from the pituitary.

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