Dr. Kyle Gillett

speaker

556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · 2 Jul 2026 podcast

Of note, spironolactone can be prescribed topically, but it is absorbed systemically because the size of the molecule.

So unless your doctor specifically prescribes that for you, especially as a male, do not use topical spironolactone.

Topical finasteride is also a smaller molecule.

So it is also systemically absorbed, but it is not extremely well systemically absorbed.

If you take topical finasteride, then usually your systemic DHT will decrease by about 30%.

Topical dutasteride is likely a tiny bit systemically absorbed, but it's unique because its half-life is much faster at a lower dose.

So topical dutasteride will not affect your systemic DHT at all.

And I've seen this anecdotally on many people on topical dutasteride therapy.

Huberman Lab · Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett · 25 Dec 2025 podcast

Thank you for having me.

So when you do a physical exam and a history, you have a lot of different parts.

You have your history of present illness.

If they have a complaint, maybe the patient doesn't have a complaint.

In that case, things like their social history and their family history are extremely important because that gives you an insight into their genetics and an insight into their hormone health.

So patients will tell me, oh, I'm doing okay, but it helps to ask them, well, how are you now?

Let's say the patient is 50.

How are you now versus when you were 20 and what has changed?

So I've gotten the question a lot, how do you get your doctor to order a better lab workup or to even include your basic hormones?

And there's no magic answer to that.

But what really helps is you tell them, you know, my energy is not as good as it used to be.

My focus is not as good as it used to be.

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