Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · 2 Jul 2026 podcast

So Tadalafil is also a blood pressure medication.

It can very slightly decrease blood pressure, especially at higher doses.

At higher doses, a high dose would be 20 milligrams, not 2.5 milligrams.

But consistently, it can somewhat affect with the cones in the eye that have to do with red and green sight.

Although if you remove it, that effect is reversed.

So basically, if you don't need really, really good red-green discrimination, you can take higher doses.

But in general, I recommend no higher than 10 milligrams a day, usually just two or five milligrams.

One other benefit or other use of Tadalafil is that it increases the density of the androgen receptor, similarly to L-carnitine.

So that's an interesting benefit.

Another benefit is that if you give it to people with nocturia, which is urinating at night in general, it will cut the episodes in half.

So it could go from two to one, which can make a big difference for your sleep, which will secondarily make a big difference for your growth hormone and testosterone optimization.

Yes.

Many people that have just a bit of predisposition, they can use things that are topical antiandrogens.

Ketoconazole is one of them.

Caffeine is actually another one.

Wait, you have to explain how this works.

Topically, the caffeine enters the scalp and crowds out, like somewhat crowds out the androgen.

It is a weak effect.

It's likely just strong enough to be clinically significant.

Usually caffeine is put into formulations with other things like ketoconazole that are also weak antiandrogens.

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