Dr. Kyle Gillett

speaker

556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett · 25 Dec 2025 podcast

Or if you have, you know, like deepening of the voice, any symptom of too much male pattern baldness, if you're a female, that's a symptom of PCOS as well.

then you can also have insulin resistance.

So this is obesity, it's prediabetes, a high fasting insulin, a HOMA-IR over two, a fasting insulin of over six.

So if you have significant insulin resistance and also androgen dominance, that's a sign of it.

Androgen dominance often leads to what's called oligomenorrhea.

So if you're having more than 35-day intervals in between a period,

or if you have less than nine per year, then that can be a sign that you have oligo, which means too little, menorrhea, which means menses.

So that's a very common sign of PCOS.

If you have infertility, so if you're under the age of 35 and you've been trying for more than a year, or if you're over the age of 35 and you've been trying for more than six months, then that can also be, it's a very common presenting complaint when somebody presents with PCOS.

If they're very strong on the insulin resistance spectrum, then optimizing their body composition, decreasing their body fat, and treating that metabolic syndrome can help.

So a lot of people ask, well, does everybody that's on, like, does everybody need to be on metformin that has PCOS?

Not necessarily, but metformin is one of the tools that can help with insulin sensitization.

Other tools that can help are inositol.

So myoinositol is an insulin sensitizer.

Its cousin, D-chiral inositol, is a weak antiandrogen.

A lot of types of inositol have both of those in it.

So depending on if you're a female or a male and you're on inositol, the type of inositol does matter.

Cannabinoids itself, whether it's THC or CBD, are not going to reduce testosterone by themselves.

If it's smoked marijuana, then it's very likely to increase your aromatase, which increases your estrogen.

and it's aromatizing from testosterone.

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