Dr. Kyle Gillett

speaker

556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett · 25 Dec 2025 podcast

So you want to have nice, even waves that are not going too far above the pool of dopamine, and prolactin will follow.

So prolactin and estrogen are quite close cousins.

Estrogen upregulates a gene called the PRL gene or prolactin gene that directly increases prolactin synthesis.

So prolactin is going to also inhibit the release of testosterone from the pituitary.

So if you're using a dopamine agonist, then you're going to help decrease the prolactin producing cells.

So if someone's concerned about dopamine, or maybe they have a slightly higher prolactin, then they eliminate things that could be increasing that prolactin.

Such as?

Casein or gluten, which are mu opioid receptor agonists or any mu opioid receptor agonist in the gut.

Casein, so milk protein?

Yeah, so just like women who spend a lot of time together, whether they're coworkers or whatever, a lot of times their menstrual cycles will align.

There is a lot of pheromonal and hormonal crosstalk, including prolactin between men and women.

So spending 100% of the time together, this is why people think it's so hard to work together and live together.

They're around each other 24 seven.

You don't have the reprieve where you let that dopamine settle down and then you're excited when you see them again.

A lot of guys know that they got on a trip for a long time.

They come back and they see their partner and it's like a new, not quite like a new relationship, but almost like a new relationship.

And they have that excitement again.

And purposely building that into every relationship can help significantly, especially if you choose to have a child or get pregnant or be breastfeeding, because you just plan ahead for both of your prolactins to be high and both of your dopamines to be low and both of your testosterone to be low.

So there's a lot of planning that you can do.

Essentially, every relationship goes through a crisis.

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