Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · 2 Jul 2026 podcast

Another is that they will be in a catabolic state more often, so that balance of anabolism and catabolism will be different.

They'll likely have less signaling from growth hormone and IGF-1.

And they'll also have the high SHBG that we defined earlier as the binding protein.

So there are free androgens and free estrogens will go down.

Stress is probably the next one.

During both puberty, but also the 20s and 30s, individuals are figuring out how they want to cope with stress and also figuring out what they want to choose to put their effort into.

So if someone is overstressed, then it can put all the other lifestyle pillars, and then they stop dieting well, they stop exercising, and everything else can go askew.

Another one is finding what your purpose is in life.

So I call this spirit, but it's really just the self-actualization component of Maslow's hierarchy of needs, which is basically your physical needs, your mental needs, and then your purpose in life, what you really like to do.

For really vigorous exercise, around three to four times a week is very sustainable over a long period of time.

On top of that, you could add in three or four more instances of less vigorous exercise.

When they study the effect of exercise, specifically vigorous exercise, one area that's been studied is vigorous exercise episodes lasting longer than an hour.

And they usually track it by a rating of perceived exertion, which isn't perfect and it's not extremely actionable, but it's helpful for clinical science.

But the takeaway from that is basically do not, it is not hormonally helpful to train, especially regularly train vigorously for longer than an hour.

Everyone has their different reason as far as when does the benefit outweigh the detriment.

Not very often if you're in your 20s, and certainly almost hardly never.

There's always rare cases like Kalman syndrome and whatnot, but almost never if you're very young.

Let's mention creatine as the first one.

Creatine is interesting because it has multiple different effects.

It helps with amino acid synthesis.

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