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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
Like people who have higher LDL later in life when it's – like your risk of dying is much more related to wasting problems.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
People who have high LDL during cancer, you're looking at a proxy for just – they're not malnourished.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
Yeah.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
And I very much doubt that if we actually looked at the raw numbers of LDL, I'm not familiar with it, but I doubt we're talking about LD people with like 250 levels of LDL.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
I bet we're talking about people who are LD of like looking at levels...
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
you know, of 40 versus, you know, 100 or 90, where like getting so far down, it's because they're so malnourished and they're wasting, right?
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
And you got to be careful about picking up these transient levels of LDL because we know LDL, transiently, if you fast, your LDL can go up, you know, because you're getting more efflux out of the liver.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
But like that overall, over the course of time, it goes down.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
So...
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
Yeah, I think, again, a Mendelian randomization study is basically a lifetime randomized control trial.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
I mean, it is, for that, the highest quality of evidence that we have.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
And people will say, well, there's pleiotropy, whatever.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
Okay, nothing's perfect.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
But again, we have mechanism penetrates the endothelium.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
We have animal studies showing a dose response.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
We have
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
actually some human randomized control trials that do show an effect.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
And we have the cohort studies that show an effect when it's long enough and they use appropriate covariates.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
So we have all those things lining up and we have the long-term randomized control trials.
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#094 Dr. Layne Norton on Building Muscle – Insights on Diet, Training, and Supplements
So I'm just like, I don't need, I don't know what other kind of evidence you need to like convince you.