Dr. Mark D'Esposito

So there's a sort of balance of dopamine.

So it's not just how much dopamine you have in your brain, it's what's the balance of the dopamine.

So I don't see a blood test as ever giving us

that information, but I do see there being a brain test that can give us this kind of information of the two, or at least a proxy for it.

So what I was thinking about when you were talking about asking this question, you know, for example, if you measure pupillary, pupil dilation, that's a pretty good proxy for the neurodegenerative system.

Yeah.

I mean, a lot of what neurology does is try to look for these windows into the brain.

And so I think there are a number of windows into the brain that we're going to be able to develop that can reflect these neuromodulatory systems.

So that's why I've been so interested in developing biomarkers because really what a neuro biomarker is, is, is trying to,

develop something you can measure easily and simply and cheaply, but gives you information about how the brain is working.

So that's a neuroprinephrine biomarker, working memory capacities that don't mean biomarker, and we're getting better at that.

But again, we're not putting enough emphasis on it, in my opinion, to really sort of help improve brain health.

Very early on, but it's such a low, you know, at the dose that my subjects were getting.

But like I said, it's so low you don't feel anything.

And I should say, even with patients that take it, they rarely get any side effects.

Sometimes with these drugs, because there's peripheral dopamine, they can get nausea or vomiting.

But it's extremely well tolerated.

You don't get any...

any anything feeling from it does it change reaction time it does and that's always the question of of how much of this is that we're just sort of speeding up we're just sort of making them faster but for all the work we've done it's pretty convincing that it's it's not just how fast you're doing it you're doing it better

Yeah, I think it kind of gets back to what we talked about there being an optimal level of dopamine in your brain.