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Dr. Mark Hyman

👤 Person
30726 total appearances

Appearances Over Time

Podcast Appearances

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

And the answer is that a very small amount of our immune system function is hardwired into our genes. The majority of our immune system function is not heritable. It is changed by the environment upon which we live that starts the moment of conception that influences our genes of our immune system and how it functions. So that's number one, which gives us room to play, right?

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

That means we can do something about it. That's good. Number two, recently technology has been developed in which you can take blood from a person, even just a finger stick of blood, and using the technology available today, you can measure aspects of the blood, which is called the epigenetic component of the blood,

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

That means we can do something about it. That's good. Number two, recently technology has been developed in which you can take blood from a person, even just a finger stick of blood, and using the technology available today, you can measure aspects of the blood, which is called the epigenetic component of the blood,

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

That means we can do something about it. That's good. Number two, recently technology has been developed in which you can take blood from a person, even just a finger stick of blood, and using the technology available today, you can measure aspects of the blood, which is called the epigenetic component of the blood,

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

to see what, using certain kinds of mathematical algorithms, your biological age is. And this has kind of become the rage recently, and you've talked about it in your podcast before, these molecular aging clocks that are developed from a blood spot. And then a person, hopefully, you know, when they get their data back, it says, oh, geez, I'm 45 years of age, but my biological age is only 35.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

to see what, using certain kinds of mathematical algorithms, your biological age is. And this has kind of become the rage recently, and you've talked about it in your podcast before, these molecular aging clocks that are developed from a blood spot. And then a person, hopefully, you know, when they get their data back, it says, oh, geez, I'm 45 years of age, but my biological age is only 35.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

to see what, using certain kinds of mathematical algorithms, your biological age is. And this has kind of become the rage recently, and you've talked about it in your podcast before, these molecular aging clocks that are developed from a blood spot. And then a person, hopefully, you know, when they get their data back, it says, oh, geez, I'm 45 years of age, but my biological age is only 35.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

That's really good. Or not so good is I'm 40 and my biological age is 60. That's not so good. Now, what are you really measuring? And this is, I think, an important thing that a lot of people don't understand. When you take a blood sample, even a blood spot, that blood that you are giving for that sample is made of three principal things. One is water and plasma proteins, that's the liquid.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

That's really good. Or not so good is I'm 40 and my biological age is 60. That's not so good. Now, what are you really measuring? And this is, I think, an important thing that a lot of people don't understand. When you take a blood sample, even a blood spot, that blood that you are giving for that sample is made of three principal things. One is water and plasma proteins, that's the liquid.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

That's really good. Or not so good is I'm 40 and my biological age is 60. That's not so good. Now, what are you really measuring? And this is, I think, an important thing that a lot of people don't understand. When you take a blood sample, even a blood spot, that blood that you are giving for that sample is made of three principal things. One is water and plasma proteins, that's the liquid.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

Second is the red stuff in the blood, which are the red blood cells, the erythrocytes, which are the predominant cells. And then about 10% are what are called the white blood cells, sometimes called the Buffy coat, and those are immune cells. So the majority of the blood that you have is not immune cells. The majority is either the plasma proteins and the erythrocytes.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

Second is the red stuff in the blood, which are the red blood cells, the erythrocytes, which are the predominant cells. And then about 10% are what are called the white blood cells, sometimes called the Buffy coat, and those are immune cells. So the majority of the blood that you have is not immune cells. The majority is either the plasma proteins and the erythrocytes.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

Second is the red stuff in the blood, which are the red blood cells, the erythrocytes, which are the predominant cells. And then about 10% are what are called the white blood cells, sometimes called the Buffy coat, and those are immune cells. So the majority of the blood that you have is not immune cells. The majority is either the plasma proteins and the erythrocytes.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

Now, it turns out that plasma proteins and erythrocytes don't have DNA. So when you're measuring then the biological age of a blood spot sample, you're actually measuring the age indirectly of the immune system. Yeah.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

Now, it turns out that plasma proteins and erythrocytes don't have DNA. So when you're measuring then the biological age of a blood spot sample, you're actually measuring the age indirectly of the immune system. Yeah.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

Now, it turns out that plasma proteins and erythrocytes don't have DNA. So when you're measuring then the biological age of a blood spot sample, you're actually measuring the age indirectly of the immune system. Yeah.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

And I think a lot of people don't understand that. They don't know that. So when they get their data back, based upon what the algorithm was used to determine biological age, they're really doing it off that cell type, your immune cell type, to see what your biological age is. And there are different ways that that data can be analyzed to give different methods of clock determination.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

And I think a lot of people don't understand that. They don't know that. So when they get their data back, based upon what the algorithm was used to determine biological age, they're really doing it off that cell type, your immune cell type, to see what your biological age is. And there are different ways that that data can be analyzed to give different methods of clock determination.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

And I think a lot of people don't understand that. They don't know that. So when they get their data back, based upon what the algorithm was used to determine biological age, they're really doing it off that cell type, your immune cell type, to see what your biological age is. And there are different ways that that data can be analyzed to give different methods of clock determination.

The Dr. Hyman Show
Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It

Now, when I read these early papers, I thought to myself, hold on, if that's the case, then don't we have now a method of interrogating the age of the immune system against the way that a person looks, acts, and feels? What happens if we start studying the age of their immune system against their headaches?