Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
All of the hairs on the back of my neck stood on a sharp end because he was saying, we've got this data and we don't quite understand it.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
We've been treating our patients.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
for blood pressure, for hypertension, using a generic drug called Prazosin.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
And Prazosin blocks the adrenergic response in the body because you're trying to sort of tamp down that sympathetic activation in the body.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
So it's a beta blocker?
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
So it's an alpha adrenergic antagonist.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
So it's not a beta blocker, but it's blocking the adrenergic system.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
And so, and it's a, you know, it's a generic, pretty cheap drug, but it turns out that it crosses the blood brain barrier.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
So it doesn't just stay within the body, it goes up into the brain.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
And he said, we don't really understand it because I've been giving patients this medication and it works to a degree, but something else happens.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
They come into the clinic and they say, doc, I don't know.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
I'm not having those nightmares anymore.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
They seem to have gone away.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
And these patients seem to start to show signs of resolution.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
So all of a sudden, I had had a model, a clinical model that was in search of data, and he had data that was in search of a theoretical model.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
couldn't believe it because it's exactly what I would predict, which is that if noradrenaline is too high in PTSD, you're not processing and stripping the emotion from the memory.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
So it keeps coming back over and over like this repetitive nightmare.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
But then if you block and help bring back down that level of noradrenaline to that, which would be seen in a normal healthy
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
In other words, completely blocking it.
Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
All of a sudden, the emotional memory gets the chance to be processed and you finally start to get symptom resolution.