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Dr. Matt Walker

πŸ‘€ Speaker
3459 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

All of the hairs on the back of my neck stood on a sharp end because he was saying, we've got this data and we don't quite understand it.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

We've been treating our patients.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

for blood pressure, for hypertension, using a generic drug called Prazosin.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And Prazosin blocks the adrenergic response in the body because you're trying to sort of tamp down that sympathetic activation in the body.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So it's a beta blocker?

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So it's an alpha adrenergic antagonist.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So it's not a beta blocker, but it's blocking the adrenergic system.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And so, and it's a, you know, it's a generic, pretty cheap drug, but it turns out that it crosses the blood brain barrier.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So it doesn't just stay within the body, it goes up into the brain.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And he said, we don't really understand it because I've been giving patients this medication and it works to a degree, but something else happens.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

They come into the clinic and they say, doc, I don't know.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

I'm not having those nightmares anymore.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

They seem to have gone away.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And these patients seem to start to show signs of resolution.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So all of a sudden, I had had a model, a clinical model that was in search of data, and he had data that was in search of a theoretical model.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

couldn't believe it because it's exactly what I would predict, which is that if noradrenaline is too high in PTSD, you're not processing and stripping the emotion from the memory.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So it keeps coming back over and over like this repetitive nightmare.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

But then if you block and help bring back down that level of noradrenaline to that, which would be seen in a normal healthy

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

In other words, completely blocking it.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

All of a sudden, the emotional memory gets the chance to be processed and you finally start to get symptom resolution.