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Dr. Matt Walker

๐Ÿ‘ค Speaker
3487 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And he said, we don't really understand it because I've been giving patients this medication and it works to a degree, but something else happens.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

They come into the clinic and they say, doc, I don't know.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

I'm not having those nightmares anymore.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

They seem to have gone away.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And these patients seem to start to show signs of resolution.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So all of a sudden, I had had a model, a clinical model that was in search of data, and he had data that was in search of a theoretical model.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

couldn't believe it because it's exactly what I would predict, which is that if noradrenaline is too high in PTSD, you're not processing and stripping the emotion from the memory.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So it keeps coming back over and over like this repetitive nightmare.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

But then if you block and help bring back down that level of noradrenaline to that, which would be seen in a normal healthy

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

In other words, completely blocking it.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

All of a sudden, the emotional memory gets the chance to be processed and you finally start to get symptom resolution.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

So we couldn't believe it.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

He flew down to Berkeley.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

We spent several days together.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

We went out to dinner.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

We just could not stop talking.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

He subsequently did some incredible work in this area.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And Prezacin went on to become an FDA-approved medication for PTSD and repetitive nightmares that was approved by the Veterans Administration.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

It seems to be, and you can look at this in terms of the electrical activity of REM sleep, the electrical brainwaves of REM sleep in these patients.

Huberman Lab
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

And you're right, it doesn't seem to be of the same electrical quality.