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Dr. Matthew Hill

๐Ÿ‘ค Speaker
1842 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

But the other one that's had a lot of attention is cannabidiol or what we call CBD. CBD is structurally looks pretty similar to THC, but doesn't behave anything like THC. It's not intoxicating at all. I'm not sure. I would probably say it's not psychoactive in the sense that people can't tell if they're on it or not.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

But I would โ€“ some people still say it's psychoactive because people claim it can affect anxiety state or mood state or other things. So in that context, maybe psychoactive is still somewhat appropriate of a word to use. Yeah.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

But I would โ€“ some people still say it's psychoactive because people claim it can affect anxiety state or mood state or other things. So in that context, maybe psychoactive is still somewhat appropriate of a word to use. Yeah.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

But I would โ€“ some people still say it's psychoactive because people claim it can affect anxiety state or mood state or other things. So in that context, maybe psychoactive is still somewhat appropriate of a word to use. Yeah.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then there's a whole bunch of other things like cannabinol, cannabigerol, and these other minor cannabinoids, most of which we really don't understand any of the biology of. We don't know what they're doing. They may influence some of the effects of THC. They may not. But they're there, and they vary in their composition from different flavor of different cannabis to different flavor.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then there's a whole bunch of other things like cannabinol, cannabigerol, and these other minor cannabinoids, most of which we really don't understand any of the biology of. We don't know what they're doing. They may influence some of the effects of THC. They may not. But they're there, and they vary in their composition from different flavor of different cannabis to different flavor.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then there's a whole bunch of other things like cannabinol, cannabigerol, and these other minor cannabinoids, most of which we really don't understand any of the biology of. We don't know what they're doing. They may influence some of the effects of THC. They may not. But they're there, and they vary in their composition from different flavor of different cannabis to different flavor.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then there's those other things called terpenes, which are kind of highly volatile compounds, but they're not specific to cannabis. They're found in tons of other plants. So this is a lot of which seems to contribute at least to some of the smell and the flavors of cannabis. So these are things like limonene, which, you know, gives some cannabis kind of a citrusy flavor. odor or flavor to it.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then there's those other things called terpenes, which are kind of highly volatile compounds, but they're not specific to cannabis. They're found in tons of other plants. So this is a lot of which seems to contribute at least to some of the smell and the flavors of cannabis. So these are things like limonene, which, you know, gives some cannabis kind of a citrusy flavor. odor or flavor to it.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then there's those other things called terpenes, which are kind of highly volatile compounds, but they're not specific to cannabis. They're found in tons of other plants. So this is a lot of which seems to contribute at least to some of the smell and the flavors of cannabis. So these are things like limonene, which, you know, gives some cannabis kind of a citrusy flavor. odor or flavor to it.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Pinene, which gives things more of like a earthy tree kind of smell. Beta-caryophyllene, myrcene. And these terpenes are also, some of which do have known biological activity, some don't. And they vary quite heavily across different kinds of cannabis as well. And again, there's some thought that they may be influencing some of the psychoactive or intoxicating properties of cannabis. But

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Pinene, which gives things more of like a earthy tree kind of smell. Beta-caryophyllene, myrcene. And these terpenes are also, some of which do have known biological activity, some don't. And they vary quite heavily across different kinds of cannabis as well. And again, there's some thought that they may be influencing some of the psychoactive or intoxicating properties of cannabis. But

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Pinene, which gives things more of like a earthy tree kind of smell. Beta-caryophyllene, myrcene. And these terpenes are also, some of which do have known biological activity, some don't. And they vary quite heavily across different kinds of cannabis as well. And again, there's some thought that they may be influencing some of the psychoactive or intoxicating properties of cannabis. But

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

The reality is we really don't know a lot about them at this point. There's kind of some emerging work that's starting to come out now that kind of plays with giving someone THC and adding in one other terpene or one other minor cannabinoid and seeing how it influences things.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

The reality is we really don't know a lot about them at this point. There's kind of some emerging work that's starting to come out now that kind of plays with giving someone THC and adding in one other terpene or one other minor cannabinoid and seeing how it influences things.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

The reality is we really don't know a lot about them at this point. There's kind of some emerging work that's starting to come out now that kind of plays with giving someone THC and adding in one other terpene or one other minor cannabinoid and seeing how it influences things.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

You can imagine with the plethora of molecules that exist in cannabis, doing this in a piecewise manner could take decades to kind of really get to a point where we understand all the interactive components of cannabis. But people tend to refer to this as like an entourage effect. That's kind of a phrase that gets used quite widely in the cannabis world. And the idea behind that is that

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

You can imagine with the plethora of molecules that exist in cannabis, doing this in a piecewise manner could take decades to kind of really get to a point where we understand all the interactive components of cannabis. But people tend to refer to this as like an entourage effect. That's kind of a phrase that gets used quite widely in the cannabis world. And the idea behind that is that

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

You can imagine with the plethora of molecules that exist in cannabis, doing this in a piecewise manner could take decades to kind of really get to a point where we understand all the interactive components of cannabis. But people tend to refer to this as like an entourage effect. That's kind of a phrase that gets used quite widely in the cannabis world. And the idea behind that is that

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

If you took pure THC, and so there are some like distillate pens and things that exist out there now in the product market, which are basically isolated THC with trace levels of anything of other stuff, would be very different than if you had THC in combination with some of these other molecules and how they might influence how THC itself is working or not.