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Dr. Paul Offit

๐Ÿ‘ค Speaker
1121 total appearances

Appearances Over Time

Podcast Appearances

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

That's why the rates of hospitalizations and death are so low. And how come- They are much, much lower than where they were before.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

T cells, T cells. Cytotoxic T cells are clearly correlated with protection against severe disease. And T cells, unlike B cells, because B cells are recognizing that's part of the spike protein, the so-called receptor binding domain, which is the business end of the spike protein that binds the cells. That's always evolving. That's always mutating away from recognition by antibodies to some extent.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

T cells, T cells. Cytotoxic T cells are clearly correlated with protection against severe disease. And T cells, unlike B cells, because B cells are recognizing that's part of the spike protein, the so-called receptor binding domain, which is the business end of the spike protein that binds the cells. That's always evolving. That's always mutating away from recognition by antibodies to some extent.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

T cells, T cells. Cytotoxic T cells are clearly correlated with protection against severe disease. And T cells, unlike B cells, because B cells are recognizing that's part of the spike protein, the so-called receptor binding domain, which is the business end of the spike protein that binds the cells. That's always evolving. That's always mutating away from recognition by antibodies to some extent.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

And T cells are not selective in that way. Conserved regions. I mean, those regions recognized by T cells have not evolved from the Wuhan 1 strain right up to the current XCC strain. It's just they've remained conserved. And so T cells is... Dan Baruch, who's a Harvard immunologist, says T cells are the unsung hero of this pandemic, and I think that's right. Wow.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

And T cells are not selective in that way. Conserved regions. I mean, those regions recognized by T cells have not evolved from the Wuhan 1 strain right up to the current XCC strain. It's just they've remained conserved. And so T cells is... Dan Baruch, who's a Harvard immunologist, says T cells are the unsung hero of this pandemic, and I think that's right. Wow.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

And T cells are not selective in that way. Conserved regions. I mean, those regions recognized by T cells have not evolved from the Wuhan 1 strain right up to the current XCC strain. It's just they've remained conserved. And so T cells is... Dan Baruch, who's a Harvard immunologist, says T cells are the unsung hero of this pandemic, and I think that's right. Wow.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

We were a blank slate. There was no population immunity to this virus. And I think you can assume this isn't the end of it. We had SARS-1 in 2002. We have MERS in 2012. Those are both pandemic coronaviruses that didn't really hit this country, but certainly could have. And now we have this virus, SARS-CoV-2, which raised its head in 2019. That's three pandemic viruses in 20 years.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

We were a blank slate. There was no population immunity to this virus. And I think you can assume this isn't the end of it. We had SARS-1 in 2002. We have MERS in 2012. Those are both pandemic coronaviruses that didn't really hit this country, but certainly could have. And now we have this virus, SARS-CoV-2, which raised its head in 2019. That's three pandemic viruses in 20 years.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

We were a blank slate. There was no population immunity to this virus. And I think you can assume this isn't the end of it. We had SARS-1 in 2002. We have MERS in 2012. Those are both pandemic coronaviruses that didn't really hit this country, but certainly could have. And now we have this virus, SARS-CoV-2, which raised its head in 2019. That's three pandemic viruses in 20 years.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

I mean, as we do things like deforestation, we live closer and closer to animals, especially bats, which are a fairly large part of the mammalian population. we are going to have another pandemic. And the thing that upsets me the most about this, we were talking about this a little earlier, is two-thirds of the American public believe this was a lab leak. And this was not a lab leak.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

I mean, as we do things like deforestation, we live closer and closer to animals, especially bats, which are a fairly large part of the mammalian population. we are going to have another pandemic. And the thing that upsets me the most about this, we were talking about this a little earlier, is two-thirds of the American public believe this was a lab leak. And this was not a lab leak.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

I mean, as we do things like deforestation, we live closer and closer to animals, especially bats, which are a fairly large part of the mammalian population. we are going to have another pandemic. And the thing that upsets me the most about this, we were talking about this a little earlier, is two-thirds of the American public believe this was a lab leak. And this was not a lab leak.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

This was an animal spillover event to human spillover event that occurred in the southwestern section of the Hunan wholesale seafood market. There are two excellent publications that show clear evidence that that virus began there.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

This was an animal spillover event to human spillover event that occurred in the southwestern section of the Hunan wholesale seafood market. There are two excellent publications that show clear evidence that that virus began there.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

This was an animal spillover event to human spillover event that occurred in the southwestern section of the Hunan wholesale seafood market. There are two excellent publications that show clear evidence that that virus began there.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

Actually, there were two separate strains, two separate lineages that both began there, either among bamboo rats or palm civets or raccoon dogs, because all the DNA from there and the genetic evidence is all right there. It's on the cages. It's on the tools that were used to brush the animals or kill the animals. It's on the tables that were there. it's all there.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

Actually, there were two separate strains, two separate lineages that both began there, either among bamboo rats or palm civets or raccoon dogs, because all the DNA from there and the genetic evidence is all right there. It's on the cages. It's on the tools that were used to brush the animals or kill the animals. It's on the tables that were there. it's all there.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

Actually, there were two separate strains, two separate lineages that both began there, either among bamboo rats or palm civets or raccoon dogs, because all the DNA from there and the genetic evidence is all right there. It's on the cages. It's on the tools that were used to brush the animals or kill the animals. It's on the tables that were there. it's all there.

The Checkup with Doctor Mike
Asking The Uncomfortable Questions About Vaccines | Dr. Paul Offit

One paper called it stall A, another one called it like stall 42 or something, but it was that stall where it started. Because otherwise you have to believe, one, that's something that's never happened before, which is that a pandemic virus was created in a laboratory. We've had a lot of pandemics. This has never happened before.