Dr. Peter Attia

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5,258 appearances 36 recordings 6 series first heard Jan 2024 last heard Jun 2025

Dr. Peter Attia’s voice in public audio — every appearance, attributed to the second.

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The Peter Attia Drive · #346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H. · 28 Apr 2025 podcast

So let me ask a silly question. Why do you publish the results of the cloning before you've gone and made the recombinant protein yourself?

Okay. So once it's published after the patent, you get to make it.

Was that known only once you started developing and you understood the kinetics of it?

Yeah, so you can't give it prophylactically because you don't know who's going to get thrombocytopenia.

What do you do? You plasmapherese the patients if you've overshot? Or not plasmapherese, platelet-pherese.

Tell folks how that drug worked, what it was for.

Why do you mechanistically, do you think that the overexpression of HER2 was impeding immune clearance? What was the thesis at the time for why overexpression of HER2 was cutting life expectancy down?

Of course, yeah.

Yeah, but I think what I really enjoy about this type of discussion though, Sue, is one, it's the story of your career, but it's also the story of oncology.

It's the story of modern oncology. So you're one of the few people whose careers takes us through the walk of modern oncology.

What was the biggest failure at that point commercially?

I almost forgot the BMT stuff. It's so archaic.

Yeah. I mean, we've got to be getting close to Avastin now too, right?

How many cells in the body, how many types of cells in the body express CD20?

But it's not as specific as CD19, is it?

Yeah, I know CD19 is on the B cell, but I didn't know the, okay.

We were talking about this earlier. This is chimeric.

Yeah, so tell folks what that implies, because that's another wrinkle in the story.

And the CD20 antibody was just also a straight naked antibody?

And targeted for an immune destruction?

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