Dr. Rhonda Patrick

And I think, you know, refined carbohydrates is something that you've mentioned.

And I think a lot of people think that refined carbohydrates definitely play a role in insulin resistance, perhaps a primary role.

But, um, aside from the obesity, as you're talking about obesity being that slow forming insulin resistance, um,

What role – can we talk a little bit deeper about carbohydrates, refined carbohydrates?

Saturated fats is also something you touched on, the ceramide as well.

We know palmitate kind of plays into that pathway.

And so what role do dietary carbs, refined versus maybe complex –

Saturated fats play.

And then is this all in the background of caloric excess or, you know, being in a deficit?

Does that matter as well?

The mixture of the two sort of like, because there's nuance here.

Let me kind of get into it.

So if you're in a caloric deficit and you're eating some refined carbs, then it's not necessarily going to – I think you have more wiggle room.

You've got to eat.

And indeed... But calories aren't an issue in that context, really.

The saturated fat scenario is that there is definitely a pathway to insulin resistance.

However, it seems as though if you're more of a ketogenic type of eater, low carb ketogenic type of eater, that pathway doesn't seem to be relevant.

I think it's problematic and not just for metabolic health, but cardiometabolic health.

I mean, that's where you get small dense LDL particles.

Again, it's the combination of the saturated fat and the refined carbohydrates.