Dr. Rhonda Patrick

I mean, this wasn't necessarily meant to treat obesity.

Yeah, right.

But I guess that it all depends on, you know, the cause of obesity.

Overeating is partly a cause of obesity, so...

Milligram.

That's interesting that in your experience, people can do this microdose and after about 90 days, they can

keep the appetite regulation under control.

Because when you look at studies with people using the clinically relevant doses that they're using now of these different GLP-1 agonists, a lot of most of the people end up gaining weight back because they go back to their old habits.

Oh, I mean, absolutely.

The way you're thinking about something changes.

can change the outcome for sure.

I want to kind of go back to something that you mentioned that was very interesting to me and it has to do with the way, you know, this food is sitting in your gut and the way digestion's kind of changed and perhaps, you know, nutrient absorption.

I hadn't really thought about it in that way because what I'm sort of alluding to is

You know, I guess it's pretty well known now is that when people are rapidly losing weight, whether it's on a GLP-1 agonist or it's from caloric restriction, they can lose a lot of muscle along with the fat.

It's not just all fat.

Particularly if people are not getting enough dietary protein, which is a big signal for muscle protein synthesis.

And if they're not engaging in resistance training, which is the other very important signal for growing muscle mass.

So...

My question to you was going to be, you know, is there a kind of a way around this muscle loss by increasing dietary protein?

Obviously the resistance training would be key, perhaps even more key now because, you know, for one, if people aren't eating, I mean, I don't know how many meals a day people are eating.