Dr. Rhonda Patrick

if metabolic health is so important for longevity, and the opposite is true, right?

Where you're metabolically unhealthy, and that is essentially accelerating aging.

You mentioned something that kind of surprised me early on, and that is you were kind of talking about mechanisms by which insulin is so damaging, independent of glucose.

And I was sitting here thinking one of the main reasons why

being metabolically unhealthy, being insulin resistant is so unhealthy is because you're having high levels of glucose, which is glycating everything from your endothelial cells lining your blood vessels to your mitocardium.

Your skin.

Your skin, proteins, DNA, lipids, everything's getting stiffer and damaged.

What are the mechanisms that are involved here with accelerating aging and- Just the glucose alone, yeah.

Well, yeah, in general.

Is it the glucose alone or what else?

What do you do with the type 1 diabetic, though?

Wow.

I was just sort of thinking about prunes because prunes are like high in sorbitol.

I also like how you're talking about this insulin-centric sort of model of how that's really the most damaging.

And it really is.

When you think about insulin, you know, shutting down, I mean...

I guess I should say that another way.

When you think about insulin's role in activating AKT, which then is shutting down all these stress response pathways, everything from autophagy to making stem cells to just everything being shut down by the action of this one hormone.

I think I told you this on a phone call where...

Again, one of my first, you know, experiments as a young biologist.