Dr. Richard Moulange

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1,784 appearances 1 recordings 1 series first heard Mar 2026 last heard 31 Mar

Dr. Richard Moulange’s voice in public audio — every appearance, attributed to the second.

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80,000 Hours Podcast · #241 – Richard Moulange on how now AI codes viable genomes from scratch and outperforms virologists at lab work — what could go wrong? · 31 Mar 2026 podcast

Oh, that's the next holy grail.

Yeah, let's take that in order.

There's a lot of different things there.

So yes, protein structure prediction, sequence to structure.

This is mostly solved.

AlphaFold3 is the most recent version of the Baker Lab you mentioned.

David Baker recently shared a Nobel Prize in chemistry in 2024 with John Jumper and Demis Hassabis, leaders at Google DeepMind.

for precisely this work on protein design, both structural prediction and design.

The Bake Lab also has their own Rosetta fold series of models, which are basically nearly as good as the AlphaFold ones.

This is mostly solved for something like, I'm sure there'll be biologists on the call who tell me this is wrong, but something like 99% of all the proteins you ever could want to have the structure of.

You can now just put it into, you know, Python using these tools and you will get something that is effectively experimentally accurate.

There will be tiny examples where we're still not quite there.

It was the subject of ongoing PhDs.

I know someone at Cambridge working on exactly this.

But boy, is the space of things that we can't predict dwindling very, very quickly.

And then we only talked about protein design, so protein MPNN and RF effusion.

Yes, I think this is not quite as developed as structural prediction, but much more developed than people think.

So there was a great paper from the Baker Lab and others last year on designing...

snake antivenoms.

This isn't as relevant for sort of catastrophic pandemics, but they were designing, I think, the world's first antivenom that works against lots and lots of different snake bites from lots of different species all in one.

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