Dr. Richard Moulange

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1,784 appearances 1 recordings 1 series first heard Mar 2026 last heard 31 Mar

Dr. Richard Moulange’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Mar 2026 with 1.

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80,000 Hours Podcast · #241 – Richard Moulange on how now AI codes viable genomes from scratch and outperforms virologists at lab work — what could go wrong? · 31 Mar 2026 podcast

That is where modern computational biology is headed.

For that to work, we're going to need all these tools really easily accessible if, in fact, you have a legitimate reason to use them and you have the right authentication.

And so I'm excited about managed access because we should be empowering defenders.

There's strong reasons to think that you can be really careful and strategic about who you give access to first.

And I'm excited to talk about that more in a moment.

Closed-wait models are generally superior, at least when we're thinking about LLMs.

And so the more sophisticated and well-resourced the actor is, the more they would only benefit from the closed-wait model.

Consider the example, again, of the Claude Code-enabled cyber attack announced at the end of 2025.

There was a reason they picked Claude Code rather than an open-wait model, because Claude Code was just much better at operating agentically than any open-wait alternative.

However, if you're trying to do something very straightforward, maybe it was just a simple biological design task, you wouldn't go with something that was closed source.

The example, the best closed biological design tool is called Alpha Proteo.

It's DeepMind's sort of version of protein MPNN.

its access is somewhat managed.

You can't just get it on the internet.

You have to email DeepMind and say, hey, I'm a legitimate scientific researcher.

I would like to use this for this legitimate purpose.

Please, could you provide it to me?

And so there's like a little bit of aspect of a sort of customer screening there.

But yes, so if you're trying to do something narrow, you might just grab the open weight model, especially if the closed weight one has a safeguard and you can't be bothered to remove it, or that would be more difficult.

So it really depends on the actor.

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