Dr. Siddhartha Mukherjee

speaker

438 appearances 1 recordings 1 series first heard Jul 2026 last heard 23 Jul

Dr. Siddhartha Mukherjee’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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The Oprah Podcast · The Alarming New Risks of Cancer Everyone Needs to Hear · 23 Jul 2026 podcast

That has been rising, so that's not an early detection problem.

And thus far, usually, endometrial cancer, early stages, is quite curable.

So it's not been reflected in increase in mortality, but it may soon be reflected at some point in time in increase in mortality.

three different cancers with three different patterns, colorectal cancer, increases in incidence, increase in mortality, breast cancer, increase in the incidence, particularly of the aggressive kinds and a plateauing or slowing down of gains in mortality.

and endometrial cancer increase in incidence and no increase in mortality yet, but we'll see.

So the sad story is that we don't know, but we're getting to know.

So virtually all cancers have some component in which, as I said, they're all genetic diseases ultimately, but many cancers have a component of the environment in it.

So it's a genes plus environment phenomenon.

So the problem is when we talk about the environment,

we talk relatively poorly about the environment.

So you just said what you eat, what you do, what exercise and other things.

But your real environment is much more complex.

It is the things that you're exposed to as a child.

It is things that are in your gut, the so-called microbiome that's in your gut.

It is things that you eat, but you may not know that you are being exposed to because you may be thinking that you're eating a very healthy diet, but some aspect of your diet might be the problem.

And finally, all the things that you're exposed to, the so-called exposome.

So again, there is that external environment, there is your genes, and there's one piece that is critically missing here.

And that is your internal environment, the environment which actually bathes your cells, your body with whatever it bathes it in.

And one very major part of that that we've discovered is the inflammation in the internal environment.

So inflammation is a sort of a bucket word.

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