Dr. Stacy Sims

So if you start having an exercise stress or a daily stress of getting up and going on with your day without fuel, you perturb those caspeptin neurons and downregulate them.

So if you start having an exercise stress or a daily stress of getting up and going on with your day without fuel, you perturb those caspeptin neurons and downregulate them.

So if you start having an exercise stress or a daily stress of getting up and going on with your day without fuel, you perturb those caspeptin neurons and downregulate them.

And so when you start down-regulating them, we see that after four days you have a dysregulation of thyroid, we have a change in our luteinizing hormone pulse, which is really important to maintain endocrine function, and we'll hear this, oh, I've been fasting for so many years and it does great for me, but the other side of the question is, well, how much better would you be if you were to actually pay attention to your circadian rhythm and fuel according to the stress at hand

And so when you start down-regulating them, we see that after four days you have a dysregulation of thyroid, we have a change in our luteinizing hormone pulse, which is really important to maintain endocrine function, and we'll hear this, oh, I've been fasting for so many years and it does great for me, but the other side of the question is, well, how much better would you be if you were to actually pay attention to your circadian rhythm and fuel according to the stress at hand

And so when you start down-regulating them, we see that after four days you have a dysregulation of thyroid, we have a change in our luteinizing hormone pulse, which is really important to maintain endocrine function, and we'll hear this, oh, I've been fasting for so many years and it does great for me, but the other side of the question is, well, how much better would you be if you were to actually pay attention to your circadian rhythm and fuel according to the stress at hand

And knowing that you're going to garner less stress that way, and if we're really tying in nutrition according to that profile instead of following a fast, we see better brain improvements as well. We see more cognitive function. We see less thyroid dysfunction. And overall, a woman does much better when we're not in that fasted state.

And knowing that you're going to garner less stress that way, and if we're really tying in nutrition according to that profile instead of following a fast, we see better brain improvements as well. We see more cognitive function. We see less thyroid dysfunction. And overall, a woman does much better when we're not in that fasted state.

And knowing that you're going to garner less stress that way, and if we're really tying in nutrition according to that profile instead of following a fast, we see better brain improvements as well. We see more cognitive function. We see less thyroid dysfunction. And overall, a woman does much better when we're not in that fasted state.

Then when you look at population research that's coming out now, they're showing in both men and women who hold their fast till noon and then have an eating window from noon to maybe 6 p.m. have more obesogenic outcomes than people who break their fast at 8 and finished their eating window by 4 or 5 p.m.

Then when you look at population research that's coming out now, they're showing in both men and women who hold their fast till noon and then have an eating window from noon to maybe 6 p.m. have more obesogenic outcomes than people who break their fast at 8 and finished their eating window by 4 or 5 p.m.

Then when you look at population research that's coming out now, they're showing in both men and women who hold their fast till noon and then have an eating window from noon to maybe 6 p.m. have more obesogenic outcomes than people who break their fast at 8 and finished their eating window by 4 or 5 p.m.

So it's coming back to the chronobiology of we need to eat when our body is under stress and needs it. Unless we have a specific issue like obesity, inactivity, PCOS, or other metabolic conditions, then we can look at using fasting as a strategic intervention to help with those modalities.

So it's coming back to the chronobiology of we need to eat when our body is under stress and needs it. Unless we have a specific issue like obesity, inactivity, PCOS, or other metabolic conditions, then we can look at using fasting as a strategic intervention to help with those modalities.

So it's coming back to the chronobiology of we need to eat when our body is under stress and needs it. Unless we have a specific issue like obesity, inactivity, PCOS, or other metabolic conditions, then we can look at using fasting as a strategic intervention to help with those modalities.

Yes, because we're looking at the way cortisol responds. We know cortisol has lots of fluctuations throughout the day, and it peaks about half an hour after you wake up, right? So if you're having that cortisol peak half an hour after you wake up, but you're not eating, then that is that higher baseline sympathetic drive for women. For men, it's not the same.

Yes, because we're looking at the way cortisol responds. We know cortisol has lots of fluctuations throughout the day, and it peaks about half an hour after you wake up, right? So if you're having that cortisol peak half an hour after you wake up, but you're not eating, then that is that higher baseline sympathetic drive for women. For men, it's not the same.

Yes, because we're looking at the way cortisol responds. We know cortisol has lots of fluctuations throughout the day, and it peaks about half an hour after you wake up, right? So if you're having that cortisol peak half an hour after you wake up, but you're not eating, then that is that higher baseline sympathetic drive for women. For men, it's not the same.

So when we're looking at that obesogenic outcome, the actual timing hasn't been tested yet. to see how can we expand or contract that eating window for men. But for women, because of that cortisol peak right after waking up, women tend to be already sympathetically driven. So then they walk around more tired but wired.

So when we're looking at that obesogenic outcome, the actual timing hasn't been tested yet. to see how can we expand or contract that eating window for men. But for women, because of that cortisol peak right after waking up, women tend to be already sympathetically driven. So then they walk around more tired but wired.