Dr. Stephanie Venn-Watson
๐ค SpeakerAppearances Over Time
Podcast Appearances
And what we started seeing, Mark, was an increase in that some of the dolphins were developing aging-associated diseases. like chronic inflammation, high cholesterol, fatty liver disease, and even the full suite of changes consistent with Alzheimer's. And what was really important was that some of the dolphins were developing these conditions, which has now culminated in what we understand
now understand as a syndrome, that some dolphins were developing this and others were not. So we were able to go in, use metabolomics, which is this advanced technology to study thousands of small molecules.
now understand as a syndrome, that some dolphins were developing this and others were not. So we were able to go in, use metabolomics, which is this advanced technology to study thousands of small molecules.
now understand as a syndrome, that some dolphins were developing this and others were not. So we were able to go in, use metabolomics, which is this advanced technology to study thousands of small molecules.
Yeah, exactly, in the blood. And we had this amazing archived inventory of dolphin serum. Look at those molecules in their blood and in their all-fish diet. to find which small molecules predicted the healthiest aging dolphins, we expected omega-3s to be at the tip top of the list.
Yeah, exactly, in the blood. And we had this amazing archived inventory of dolphin serum. Look at those molecules in their blood and in their all-fish diet. to find which small molecules predicted the healthiest aging dolphins, we expected omega-3s to be at the tip top of the list.
Yeah, exactly, in the blood. And we had this amazing archived inventory of dolphin serum. Look at those molecules in their blood and in their all-fish diet. to find which small molecules predicted the healthiest aging dolphins, we expected omega-3s to be at the tip top of the list.
And instead it was C15, which none of us even knew what C15 was, but pentadecanoic acid was the top predictor of healthy aging dolphins. So that was 10 years ago and what started the next 10 years of research now over 100 papers on C15.
And instead it was C15, which none of us even knew what C15 was, but pentadecanoic acid was the top predictor of healthy aging dolphins. So that was 10 years ago and what started the next 10 years of research now over 100 papers on C15.
And instead it was C15, which none of us even knew what C15 was, but pentadecanoic acid was the top predictor of healthy aging dolphins. So that was 10 years ago and what started the next 10 years of research now over 100 papers on C15.
Right, right. So the first important discovery that we made, and this was alongside Dr. Ed Dennis, who's a leader in fatty acids. So he was the editor-in-chief for the Journal for Lipid Research for 15 years. And when we first made the discovery of C15 association, right, because in the dolphins, this was just association with better health.
Right, right. So the first important discovery that we made, and this was alongside Dr. Ed Dennis, who's a leader in fatty acids. So he was the editor-in-chief for the Journal for Lipid Research for 15 years. And when we first made the discovery of C15 association, right, because in the dolphins, this was just association with better health.
Right, right. So the first important discovery that we made, and this was alongside Dr. Ed Dennis, who's a leader in fatty acids. So he was the editor-in-chief for the Journal for Lipid Research for 15 years. And when we first made the discovery of C15 association, right, because in the dolphins, this was just association with better health.
we went to Dr. Dennis to Ed and shared our hypothesis and Ed was like, well, chances are this isn't gonna pan out because we've known about C-15 since the 1950s and chances are that stuff, no offense, that a dolphin veterinarian didn't discover something new about fatty acids. And he's like, but it's intriguing about the dolphins. So we spent the next three years
we went to Dr. Dennis to Ed and shared our hypothesis and Ed was like, well, chances are this isn't gonna pan out because we've known about C-15 since the 1950s and chances are that stuff, no offense, that a dolphin veterinarian didn't discover something new about fatty acids. And he's like, but it's intriguing about the dolphins. So we spent the next three years
we went to Dr. Dennis to Ed and shared our hypothesis and Ed was like, well, chances are this isn't gonna pan out because we've known about C-15 since the 1950s and chances are that stuff, no offense, that a dolphin veterinarian didn't discover something new about fatty acids. And he's like, but it's intriguing about the dolphins. So we spent the next three years
doing eight studies to show that C15 not only has direct benefits and is a beneficial saturated fat, like you shared, but that it meets these rare criteria of being an essential fatty acid, the first essential fatty acid to be discovered in over 90 years.
doing eight studies to show that C15 not only has direct benefits and is a beneficial saturated fat, like you shared, but that it meets these rare criteria of being an essential fatty acid, the first essential fatty acid to be discovered in over 90 years.
doing eight studies to show that C15 not only has direct benefits and is a beneficial saturated fat, like you shared, but that it meets these rare criteria of being an essential fatty acid, the first essential fatty acid to be discovered in over 90 years.
Yeah, so what we've learned is that our bodies require a certain amount of C15 in our bodies, including in our cell membrane. It's a sturdy saturated fat. That is because it's an odd chain saturated fatty acid, has an odd number of carbons, it has anti-inflammatory properties. We'll talk about all the different mechanisms that C15 has.