Dr. Stephanie Venn-Watson
๐ค SpeakerAppearances Over Time
Podcast Appearances
protects us against this lipid peroxidation, the attack of oxygen, and that prolongs life. There's actually a really cool theory that comes from A.J. Holbert, where he showed that the more stable and sturdy fatty acids in the cell membranes are, the longer a species lives.
protects us against this lipid peroxidation, the attack of oxygen, and that prolongs life. There's actually a really cool theory that comes from A.J. Holbert, where he showed that the more stable and sturdy fatty acids in the cell membranes are, the longer a species lives.
So it's already, you know, nature has already figured this out, exactly what you said of how a human and a dolphin can live 20 to 30 times longer than a mouse. So let's not start by trying to figure out how to help mice live longer. Let's start by understanding how us long-lived species live a long time and then push and optimize that.
So it's already, you know, nature has already figured this out, exactly what you said of how a human and a dolphin can live 20 to 30 times longer than a mouse. So let's not start by trying to figure out how to help mice live longer. Let's start by understanding how us long-lived species live a long time and then push and optimize that.
And so that's what we've been able to do with the Navy and C-15.
And so that's what we've been able to do with the Navy and C-15.
Yeah, that's right. And in fact, there was this discovery of a whole new form of cell death called varroptosis. And this was discovered by Columbia University researchers back in 2012. And that's where they found that when we went to medical school or took our cell biology class, we learned there were three ways our cells die. This group discovered a fourth.
Yeah, that's right. And in fact, there was this discovery of a whole new form of cell death called varroptosis. And this was discovered by Columbia University researchers back in 2012. And that's where they found that when we went to medical school or took our cell biology class, we learned there were three ways our cells die. This group discovered a fourth.
And this form of theroptosis is exactly what you said, where it's this attack of oxygen on fragile fatty acids in the cell membrane that That leads to everything, Dr. Ju, you just described. It takes out our mitochondria, it leads to reactive oxygen species.
And this form of theroptosis is exactly what you said, where it's this attack of oxygen on fragile fatty acids in the cell membrane that That leads to everything, Dr. Ju, you just described. It takes out our mitochondria, it leads to reactive oxygen species.
While that used to be a slow process that happens over time, what we're now seeing is with this process and this new cell death that for optosis is accelerated. And so this accelerated aging process is happening. Nobody really understood why fructose showed up until we'll talk about the dolphins. Go ahead.
While that used to be a slow process that happens over time, what we're now seeing is with this process and this new cell death that for optosis is accelerated. And so this accelerated aging process is happening. Nobody really understood why fructose showed up until we'll talk about the dolphins. Go ahead.
Yeah, this unexpected surprise, right? As a veterinary epidemiologist, I was working to continually help improve the health and welfare of the Navy's dolphins.
Yeah, this unexpected surprise, right? As a veterinary epidemiologist, I was working to continually help improve the health and welfare of the Navy's dolphins.
That's when we discovered that about one in three of Navy dolphins, as they got older, developed things that are going to sound familiar, like high cholesterol, chronic inflammation, insulin resistance, and fatty liver disease, and even changes consistent with Alzheimer's in the brain.
That's when we discovered that about one in three of Navy dolphins, as they got older, developed things that are going to sound familiar, like high cholesterol, chronic inflammation, insulin resistance, and fatty liver disease, and even changes consistent with Alzheimer's in the brain.
So because the dolphins are such a clean population, they don't smoke, they don't drink, they have a very clean diet and consistent health care.
So because the dolphins are such a clean population, they don't smoke, they don't drink, they have a very clean diet and consistent health care.
I know, maybe they need dolphins. They might be getting some drinking in there. But we were able to use this advanced technology called metabolomics to study thousands of small molecules in their archived serum and in their all-fish diet. And that's where we discovered it was C15 of 460 different molecules present in our, in the dolphin's blood.
I know, maybe they need dolphins. They might be getting some drinking in there. But we were able to use this advanced technology called metabolomics to study thousands of small molecules in their archived serum and in their all-fish diet. And that's where we discovered it was C15 of 460 different molecules present in our, in the dolphin's blood.