Dr. Stephanie Venn-Watson

And this form of theroptosis is exactly what you said, where it's this attack of oxygen on fragile fatty acids in the cell membrane that That leads to everything, Dr. Ju, you just described. It takes out our mitochondria, it leads to reactive oxygen species.

And this form of theroptosis is exactly what you said, where it's this attack of oxygen on fragile fatty acids in the cell membrane that That leads to everything, Dr. Ju, you just described. It takes out our mitochondria, it leads to reactive oxygen species.

While that used to be a slow process that happens over time, what we're now seeing is with this process and this new cell death that for optosis is accelerated. And so this accelerated aging process is happening. Nobody really understood why fructose showed up until we'll talk about the dolphins. Go ahead.

While that used to be a slow process that happens over time, what we're now seeing is with this process and this new cell death that for optosis is accelerated. And so this accelerated aging process is happening. Nobody really understood why fructose showed up until we'll talk about the dolphins. Go ahead.

Yeah, this unexpected surprise, right? As a veterinary epidemiologist, I was working to continually help improve the health and welfare of the Navy's dolphins.

Yeah, this unexpected surprise, right? As a veterinary epidemiologist, I was working to continually help improve the health and welfare of the Navy's dolphins.

That's when we discovered that about one in three of Navy dolphins, as they got older, developed things that are going to sound familiar, like high cholesterol, chronic inflammation, insulin resistance, and fatty liver disease, and even changes consistent with Alzheimer's in the brain.

That's when we discovered that about one in three of Navy dolphins, as they got older, developed things that are going to sound familiar, like high cholesterol, chronic inflammation, insulin resistance, and fatty liver disease, and even changes consistent with Alzheimer's in the brain.

So because the dolphins are such a clean population, they don't smoke, they don't drink, they have a very clean diet and consistent health care.

So because the dolphins are such a clean population, they don't smoke, they don't drink, they have a very clean diet and consistent health care.

I know, maybe they need dolphins. They might be getting some drinking in there. But we were able to use this advanced technology called metabolomics to study thousands of small molecules in their archived serum and in their all-fish diet. And that's where we discovered it was C15 of 460 different molecules present in our, in the dolphin's blood.

I know, maybe they need dolphins. They might be getting some drinking in there. But we were able to use this advanced technology called metabolomics to study thousands of small molecules in their archived serum and in their all-fish diet. And that's where we discovered it was C15 of 460 different molecules present in our, in the dolphin's blood.

This population of dolphins gave us the gift, the secret showing that C15, this odd chain saturated fatty acid helped explain why the healthy aging dolphins were aging healthier. Since then, over a hundred peer reviewed papers published by folks from around the world have

This population of dolphins gave us the gift, the secret showing that C15, this odd chain saturated fatty acid helped explain why the healthy aging dolphins were aging healthier. Since then, over a hundred peer reviewed papers published by folks from around the world have

showing that C15 is not only essential, but is now a key to sustaining our long-term metabolic heart and liver health and therefore our longevity.

showing that C15 is not only essential, but is now a key to sustaining our long-term metabolic heart and liver health and therefore our longevity.

That is correct. So we published last year what's called cellular fragility syndrome. So if something is essential, part of the definition of essentiality means that if you take it out of your diet, which is exactly like you said, has happened as we decreased our intake of dairy fat. that you would expect to see a deficiency like vitamin C deficiency in scurvy and vitamin D deficiency in rickets.

That is correct. So we published last year what's called cellular fragility syndrome. So if something is essential, part of the definition of essentiality means that if you take it out of your diet, which is exactly like you said, has happened as we decreased our intake of dairy fat. that you would expect to see a deficiency like vitamin C deficiency in scurvy and vitamin D deficiency in rickets.

So what we found was C15 deficiency makes cells more fragile. They break down faster, cause this new form of cell death. Reptosis is present in as many as one in three of us. And in fact, maybe explaining this rise we're seeing in type two diabetes, coronary heart disease, and fatty liver disease, especially among younger people born since the 1990s.

So what we found was C15 deficiency makes cells more fragile. They break down faster, cause this new form of cell death. Reptosis is present in as many as one in three of us. And in fact, maybe explaining this rise we're seeing in type two diabetes, coronary heart disease, and fatty liver disease, especially among younger people born since the 1990s.