Dr. Todd LePine

But they remember going on a trip to Hawaii and they end up in the hospital with bloody diarrhea. And then ever since then, nothing's been the same.

But they remember going on a trip to Hawaii and they end up in the hospital with bloody diarrhea. And then ever since then, nothing's been the same.

But they remember going on a trip to Hawaii and they end up in the hospital with bloody diarrhea. And then ever since then, nothing's been the same.

Well, so based on culturing the bowel, we've been able to isolate that 60% of IBS is SIBO. The other 40% is a mixed bag. So for example, and you probably talk about this now, Ehlers-Danlos syndrome, POTS syndrome, we're starting to recognize those illnesses as characteristically GI-centric, at least in their early presentations as well.

Well, so based on culturing the bowel, we've been able to isolate that 60% of IBS is SIBO. The other 40% is a mixed bag. So for example, and you probably talk about this now, Ehlers-Danlos syndrome, POTS syndrome, we're starting to recognize those illnesses as characteristically GI-centric, at least in their early presentations as well.

Well, so based on culturing the bowel, we've been able to isolate that 60% of IBS is SIBO. The other 40% is a mixed bag. So for example, and you probably talk about this now, Ehlers-Danlos syndrome, POTS syndrome, we're starting to recognize those illnesses as characteristically GI-centric, at least in their early presentations as well.

So some of the leftover 40% have Ehlers-Danlos syndrome or POTS, or some of them are celiac that we've missed. Some of them are food sensitivities. Some of them are histamine sensitivities. Some of them are So it's a mixed bag of a number of other disorders. And some of them are fungal overgrowth. So we see that in about 6% to 10% of that 100 pi. So there's still more to unpackage.

So some of the leftover 40% have Ehlers-Danlos syndrome or POTS, or some of them are celiac that we've missed. Some of them are food sensitivities. Some of them are histamine sensitivities. Some of them are So it's a mixed bag of a number of other disorders. And some of them are fungal overgrowth. So we see that in about 6% to 10% of that 100 pi. So there's still more to unpackage.

So some of the leftover 40% have Ehlers-Danlos syndrome or POTS, or some of them are celiac that we've missed. Some of them are food sensitivities. Some of them are histamine sensitivities. Some of them are So it's a mixed bag of a number of other disorders. And some of them are fungal overgrowth. So we see that in about 6% to 10% of that 100 pi. So there's still more to unpackage.

We're not ignoring the other 40. We're trying to figure the rest out. But it's a little bit more. harder to unravel.

We're not ignoring the other 40. We're trying to figure the rest out. But it's a little bit more. harder to unravel.

We're not ignoring the other 40. We're trying to figure the rest out. But it's a little bit more. harder to unravel.

Yeah, I mean, Dr. Satish Rao in Georgia has done a lot of the seminal work in this. But more recently, we've done shotgun sequencing of the small intestine, and we've been seeing this fungal overgrowth.

Yeah, I mean, Dr. Satish Rao in Georgia has done a lot of the seminal work in this. But more recently, we've done shotgun sequencing of the small intestine, and we've been seeing this fungal overgrowth.

Yeah, I mean, Dr. Satish Rao in Georgia has done a lot of the seminal work in this. But more recently, we've done shotgun sequencing of the small intestine, and we've been seeing this fungal overgrowth.

No, shotgun sequencing means we sequence every single piece of DNA we can find and then characterize it and see what organisms it represents. And it represents fungus about 10% of the time. And that when the fungus is higher, the patients are experiencing more abdominal pain and more diarrhea.

No, shotgun sequencing means we sequence every single piece of DNA we can find and then characterize it and see what organisms it represents. And it represents fungus about 10% of the time. And that when the fungus is higher, the patients are experiencing more abdominal pain and more diarrhea.

No, shotgun sequencing means we sequence every single piece of DNA we can find and then characterize it and see what organisms it represents. And it represents fungus about 10% of the time. And that when the fungus is higher, the patients are experiencing more abdominal pain and more diarrhea.

So there is a subclass of these patients that it is fungal, but it's smaller than some would like to believe, but larger than those who are naysayers, as you've probably heard. And so it is there, it's real, but it's a little more challenging to identify. There's no breath test for it. You got to go in and chase it. And that's the challenge.

So there is a subclass of these patients that it is fungal, but it's smaller than some would like to believe, but larger than those who are naysayers, as you've probably heard. And so it is there, it's real, but it's a little more challenging to identify. There's no breath test for it. You got to go in and chase it. And that's the challenge.