Dr. Yousef Elyaman

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46 appearances 1 recordings 1 series first heard Apr 2025 last heard Apr 2025

Dr. Yousef Elyaman’s voice in public audio — every appearance, attributed to the second.

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The Dr. Hyman Show · Fatty Liver Is the New Smoking—And 90 Million Americans Have It · 7 Apr 2025 podcast
Other than that.
So one of the major things is food, right? So food and insulin resistance is kind of at the top of the list. So our food, there's more sugar being added to our foods. There's higher carbohydrates. But when you look a little bit deeper into it, high uric acid as well. So that comes from eating too much fructose. Fructose, which is like high fructose corn syrup in all our...
So we have high fructose corn syrup. Alcoholism is on the rise. So alcohol is a toxin. So that also is going to affect the liver, along with small intestinal bacterial overgrowth. So bad bacteria in the gut. The gut can be as metabolically active as the cytochrome P450. Yeah.
And because of our current lifestyles, the bacteria in our gut or in our intestines are changing, and they're changing for the worst. And there is an association between small intestinal bacterial overgrowth, which is one of the major causes of irritable bowel syndrome, and having fatty liver disease.
Absolutely, right, right. Yeah, what did you say, a food baby? Food baby, you know, that bloating thing. That food pregnancy. Right. Yeah, so one alarming statistic, they looked at young men that were not overweight, And they found that they did something called a insulin resistance score test on them. And they found that more than half of them had insulin resistance.
And these are young men in their 20s, not overweight, normal ideal weight. So I think that kind of brings us to one of the first drivers, which is this insulin resistance concept.
Yeah, their blood sugar normal.
Correct? It's the huge driver of fatty liver disease. I would say it's the number one driver, but there are eight or nine drivers. So what happens is that due to inflammation, due to toxicity, due to too much sugar, like too much of a sugar overload or a carbohydrate overload,
when those receptors on our fat cells, we have these insulin receptors that are supposed to take sugar and put sugar into the cells. When they start to not work well, when they start to get resistant, there is an enzyme called hormone sensitive lipase. And what that enzyme does is it starts tearing up the fat in the fat cell and it sends the fat to the liver and it overloads the liver.
So now you have this liver that gets overloaded. So the liver ends up with a whole bunch of triglycerides, which is one of the tests that we look on the lipid panel. Now, here's the interesting thing. So you could check a triglyceride level, and their level would look okay. And that's because some people genetically will decrease triglycerides in the blood. Increase it a lot.
What the triglycerides do, when you end up sending a whole bunch of triglycerides to the liver, they turn into something called VLDL. Very low density lipoprotein. Triglyceride rich VLDL versus triglyceride poor. And VLDL becomes, there's another enzyme found in the lining of our blood vessel that is called lipoprotein lipase. And it turns it into the tiny dense LDL.
which causes clogging of the blood vessel and heart disease, strokes, and heart attacks.
Right, yeah. What's happening in the liver? So what's happening in the liver? So we can go back to what's happening in the fat and then go right back to the liver. So number one, the fat starts to send the triglycerides to the liver and start overloading the liver.
When that process is overloaded, then your fat cells, which actually your fat is, I don't know if you've done a podcast on this, but your fat is like an endocrine organ. It makes things like adiponectin. When the process is bad, adiponectin levels can go down, which causes more insulin resistance and more inflammation.
And then there are other hormones that can go up in the liver that can cause inflammation, like tumor necrosis factor. like leptin, so those go up and now that inflammation and worsening insulin resistance and all that fat make its way throughout the body and they go in the liver and the liver starts to accumulate and accumulate and accumulate and it just can't keep up with it.
The liver packages it and sends it back to the fat. The fat takes it up. But then because of the insulin resistant, it shoots it right back to the liver. And you end up with this vicious cycle. In the meantime, the liver is not supposed to be storing fat. The liver is supposed to be making all these metabolic processes. It's supposed to repackage the fat.
And now when it gets overloaded and jam-packed, Now the liver starts to get inflamed. It starts to rust, oxidative stress. Sugar starts to get worse. And it kind of creates this metabolic nightmare.
It's a vicious cycle.
Right. And see, and the thing is, I mean, we could just go, we could probably do a whole podcast on when you have fatty liver, all of the other imbalances, all of the other things that are thrown off in the human body.
Unfortunately, too many providers, too many doctors take a look at, say, oh, you have fatty liver, lose weight, and they don't really talk to them about it again, when really that is driving heart disease. It's driving Alzheimer's disease. It's driving cancer. The liver is supposed to be metabolizing our toxins. So now your liver is not working. It causes hormone imbalances.
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