Eric Topol

Yeah.

So let's get right into the topic.

The connection between sleep and neurodegenerative disease, particularly Alzheimer's, what's your overall perspective about how they come together?

All right.

Well, so you made the link between the two most important neurodegenerative diseases, Alzheimer's and Parkinson's.

But regarding the mechanism, is this really related to the primacy of deep sleep, the slow wave portion of sleep, or is it really other phases as well?

Yeah, so you've confirmed that, and that's a great set of experiments.

It's quite unique.

And, you know, these people that went to two sleep studies and then had the lumbar puncture, I mean, well, I give them a lot of credit.

Now, 17, which obviously has attracted lots of attention, as well as these other neuroinflammation markers,

Are there any data to show that the plasma blood level of PTAL 217 is affected directly by deep sleep?

Oh, that'll be interesting.

We're starting a prevention of Alzheimer's trial next month.

with 1200 people, very high risk with high P tau 217 and other factors.

And we're gonna look at the effects of sleep on their P tau 217 over the course of a year.

So we'll have some complimentary data to what you get at, but it'd be really interesting.

I want to get back to the orexin drugs in a minute.

But this story about sleep is much bigger than just neurodegenerative disease and health because what we've seen, for example, the remarkable relationship of sleep regularity, the index,

And across the board, cardiovascular, cancer, and neurodegenerative, the three big age-related diseases.

How does this remarkable sleep connection, if you want to call it association or even if you want to consider possible cause and effect, how does it cut across all these different diseases?