Eric Topol

And secondly, as you also pointed out, the weight of the evidence is that it's a sleep-dependent phenomena, particularly during slow-wave deep sleep, at least what I've seen.

Also interesting, your point about it being dynamic, which is fascinating.

There was a paper in my field of cardiology.

People with atrial fibrillation had less active lymphatics, less clearance, which was really interesting.

And then the other finding that's also noteworthy was that Ambien made things worse.

What do you think about that?

And it's interesting that we may have a sleep medicine, finally, or a class that actually is doing what is desired, right?

I mean, especially on... This is one of the other things I was going to ask you about is that

As you pointed out, this is an interaction throughout the organism, throughout the human being.

And we've seen studies about how sleep disrupts metabolism.

And through that, of course, and even separately, can take down our immune system or disrupt that as well.

And so one of the questions, I guess, is your thoughts about these other effects, because you mentioned, of course, the potential of looking at things like P tau 217 markers or other markers that would denote the status of your ultimate risk for moving on to Alzheimer's disease.

But there's these other factors that also play a role with lack of adequate sleep and perhaps particularly sleep quality.

I wonder if you could just comment about this because there's so many different systems of the body that are integrated here.

And so, you know, the salutary effect that you just described with the ability to potentially see less at least biomarkers for what would be considered risks to ultimately develop Alzheimer's.

There's also these other very important effects when we talk about high quality sleep, I guess.

Right.

And maybe you could comment about that.

Yes, and the other thing that you've emphasized, and I just want to reiterate to people listening or watching, that is the regularity story.

Just like you said with quality, the data, and I'll put the figure in that shows the link between regularity and cardiovascular, neurodegenerative, cancer, that regularity thing, a lot of people don't understand how important that is at all.