Eric Topol

Yeah, I have patients that are coming to me saying, my VO2 max is dropping.

I'm getting really worried.

We don't know.

Which could explain, ultimately, I hope that the study will be done with the device implant where some people will respond, hopefully, and POTS can be terribly refractory.

difficult to treat, and others might not because of that point you just raised.

Now, just in wrapping up, one of my colleagues here got the Nobel Prize for the Piezo-2 receptors.

And, you know, that, of course, is Arnab Patapushin.

That connects with the vagal nerve.

the vagus nerve uses the, I mean, the PESO2 receptors are everywhere, but that is, of course, you might want to just comment about bringing those two things together.

Well, I mean, I think just to pull it together, you really deserve tremendous credit, Kevin, for bringing in the field of the inflammatory reflex using a device that could be implanted

that could knock down inflammation, as we've seen for autoimmune diseases.

First one out of the block proven, rheumatoid arthritis, many more to come.

likely inflammatory bowel disease and many others.

But what you've also, I think, confronted, it's taken you decades to do this because we live in a world of pharmaceuticals, right?

And pharmaceutical companies, you know, the device companies that are trying to do this stuff are, you know, like the Rodney Dangerfields.

You know, they don't get a lot of funding.

They have struggles.

for many years.

It's a big slog.

But I have to say, you know, if I had an autoimmune disease, if I had to take a drug that would knock down my immune system and put me at some risk versus having an outpatient implant...