Eric Topol

And when you think about your parents, just because it doesn't run in your mother or your father's lineage, the point is you're getting this combination of genes.

You could have a very different type of risk when you have this combination of genomic variants.

So that's why polygenic risk scores are independently useful in determining the risk of a person not discernible from their family history.

Yeah, that's a really important question because you practice what you preach, right?

So doing all the research for super agers changed my position.

I always was an advocate for aerobics and I had not done hardly any resistance training or balance training.

And now I'm onto that several times a week.

So that was a big change.

The second big change for me was I had very chaotic sleep habits of staying up very late and now

That's a big thing.

I've taken my deep sleep from various things, particularly regularity, up from a terrible number.

It's in the right direction.

I wish it was even better.

In addition to all that, because my polygenic risk score tells me I'm at high risk for heart disease, even though it never was in either parent, I was taking a statin.

But then I developed terrible muscle cramps.

So I want to keep my LDL very low.

And so I'd done that with the injectable drug, Repatha, that I take.

And the polygenic risk score should be routine.

I don't know why the medical community doesn't adopt it universally, but that helps to at least know about the risk.

And of course, there are other ways, as I mentioned, that we will know.