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Eric Topol

๐Ÿ‘ค Speaker
See mentions of this person in podcasts
3037 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Yeah, every dog I've had had the same problem.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Never let the ball go.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And that's kind of like the metaphor is powerful.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

So you figure out how to do this, which is with no reagents.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

This is unlike a continuous glucose sensor or a lactate sensor.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

No reagents, a little tiny bit of electricity.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And then you sense the protein level.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And then you go ahead and you say, okay, let's try this in a diabetic rat model.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And you're looking for specific inflammation proteins like interleukin-6, tumor necrosis factor.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And what did you find when you did that?

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

I was struck by that especially.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Yeah, yeah.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Yeah.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

So this is why it was such a landmark contribution, because no one had ever really conceived that this could be possible.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

But you actually demonstrated it is more than possible.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

You demonstrated it in a very

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

impressive animal model.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Now, there seems to be limitless clinical applications of this.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

I mean, so, you know, if you were trying to monitor if a person's eating an anti-inflammatory diet or they're exercising and they're keeping their body in their low levels of inflammation, which we know inflammaging is such a big part of

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

how we wind up with these age-related diseases.