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Appearances Over Time

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Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And it's about a virus that gets wings.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

and circles around the world in hours, I guess starting in Somalia and then getting into your neck of the woods in Minneapolis.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And it's obviously something that you imagined, but it's maybe not so far off from what could happen.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

So take us through the SARS-3 scenario that you envisioned.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

Well, you've been doing that quite a while.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

This is a culmination of that work.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

But, you know, one of the many, many quotes that are in the book that really hit me

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

is the one from Joshua Lederberg.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

The single biggest threat to man's continued dominance on the planet is the virus, the virus.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And you, of course, know this perhaps better than anyone about what a virus is capable of doing.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And as you outlined, you know, what if you had the combination of a MERS virus

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

and an Omicron that could spread like wildfire, but also wasn't just as, at times for younger, healthier people, you know, relatively, not relatively innocuous.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

Of course, it could still cause long COVID in those people, but now we have potential, it could be something much worse.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And some people would say it's just a matter of time, but I want to go now to the, well, that term that you can, you coined so many microbial 911, you know, at,

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

That's right there.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

When you get to SARS-2, our current pandemic, endemic, whatever you want to call it,

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

There's many things.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

You said there were eight major mistakes, right?

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And right at the top of the list was the whole denial of airborne transmission with this thing about fixation.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

Oh, it's the liquid droplets.