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Eric Topol

๐Ÿ‘ค Speaker
See mentions of this person in podcasts
3037 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

Maybe you could tell us a bit about that.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

Wow, that's great.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

Now, Jennifer, this IGI that you founded a decade ago,

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

It's doing all kinds of things that are even well beyond rare diseases.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

You know, we recently spoke, I know, on Ground Truths about things as diverse as editing the gut microbiome for an asthma and potentially someday Alzheimer's.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

But here you were very much involved, IGI, with the KJ, baby KJ microbiome.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

Muldoon.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

Maybe you could take us through this because this is such an extraordinary advance in the whole CRISPR cure story.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

It's so amazing.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

I don't think people necessarily graph this.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

This timeline that we'll post with this,

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

It's just mind-boggling how you could, as you said, Jennifer, in about six months, to go from the birth and sequencing through cell-specific cultures with the genome mutations, through multiple experimental models with non-human primates even,

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

looking at off-target effects, you know, through the multiple FDA reviews, and then dosing, you know, cumulatively three dosing to save this baby's life.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

It's really just amazing.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

Now, that is a template.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

And before we go to this new center, I just want to also mention not just a timeline of compression, which is unimaginable,

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

and the partnership that you've had at IGI with, I guess, Donaher to help manufacture, which is just another part of the story.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

But also the fact that you're not just even with CRISPR 1.0 as being used in the approvals previously for sickle cell and beta thalassemia, but now we're talking about base editing in vivo, in the body, using mRNA delivery.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

So maybe you could comment on that, Jennifer.

Ground Truths
Priscilla Chan & Jennifer Doudna: New Center for Pediatric CRISPR Cures

Yeah, no, it is amazing.