Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh

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917 appearances 1 recordings 1 series first heard Jul 2026 last heard 28 Jul

Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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This Podcast Will Kill You · Ep 217 The High Stakes of Cholesterol · 28 Jul 2026 podcast

Where do we get it from?

Let me tell you.

We make our own cholesterol and most all of our cells can make cholesterol, like all of our cells are capable of it, but it's a pretty energy intensive process.

So the vast majority of cholesterol that we actually use in our body is made in our liver.

And then we also get cholesterol and other fats and fatty acids that we also need from our diet.

So we absorb it through our intestine, and then that gets transported to our liver.

So while our cells can make their own cholesterol, they're generally not making quite enough of it, which is why our liver makes so much, something like more than 50% of the cholesterol that our cells use.

Which means that we have to be able to deliver cholesterol from our liver and our intestine to everywhere else in our body.

Yeah.

And our body uses blood to transport stuff around.

Okay.

It's the super highways of the body.

Exactly.

And so while cholesterol is integral to life, when it ends up causing problems, which is obviously what we're going to focus on for this episode, is when that cholesterol starts building up in high amounts in places that it shouldn't.

That is where we can end up seeing cholesterol cause disease.

And so to understand how that happens, we have to understand how it is that our body is moving cholesterol around from our liver to our cells, et cetera, and how our cells are cycling that cholesterol, because then we can understand how this might build up in places that it shouldn't.

Now, lipids, a key thing to understand about them, including cholesterol and all of our other fatty acids, is that they are not water-soluble, right?

Everyone who's tried to make salad dressing knows this.

And what that means is that in order to move cholesterol around our bloodstream, it's not just going to be free-floating because it won't do that well.

So we actually move our cholesterol around our body in little packages called lipoproteins.

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