Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh

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917 appearances 1 recordings 1 series first heard Jul 2026 last heard 28 Jul

Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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This Podcast Will Kill You · Ep 217 The High Stakes of Cholesterol · 28 Jul 2026 podcast

Some of that might have to do with your dietary factors.

We know that diets that are high in fat, especially saturated fat, increase the total amount of all these types of cholesterol in your bloodstream, all these different cholesterol packages.

We don't know why, though.

It also is going to depend on how good your cells are at taking this cholesterol out of your bloodstream.

And one of the main things that determines that is how many what are called LDL receptors you have on your cells.

These are like Velcro mitts that grab on to those LDL packages of cholesterol really efficiently and pull them into the cells so that those cells can use them.

But if you don't have as many LDL receptors or your LDL receptors are not as functional as someone else's or they just get saturated because you end up with so much of that LDL cholesterol package floating around that all your receptors are full, right?

then you're going to have more of that LDL cholesterol in your body.

And what determines how much HDL cholesterol you have is even more unknown because there's definitely like a big genetic factor there, but we don't know like why is it that some people's cells are exporting more HDL and others aren't.

And the VLDL-LDL is just sort of like that's just a natural progression?

It's a progression, yeah.

And again, it is going to vary person to person, like how quickly that VLDL breaks down into LDL within your bloodstream while it's like bumping around.

But it's all very like person dependent.

There's not like a lot of...

of specific gases.

So it's so tricky because yeah, there are so many different drivers of LDL.

Right.

Like why, why?

Okay.

This is getting in a little bit to the evolution question of this, but like, why would it be more beneficial to have more LDL receptors or fewer receptors?

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