Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh

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917 appearances 1 recordings 1 series first heard Jul 2026 last heard 28 Jul

Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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This Podcast Will Kill You · Ep 217 The High Stakes of Cholesterol · 28 Jul 2026 podcast

It really is.

Yeah.

In case you were curious, cholesterol comes from cholesterine, which was the name given to it in 1815 by Michel Chevreul, who had isolated the stuff from human gallstones.

So CHOLE is bile and stereosolid.

Solid bile.

Okay, interesting.

So when did people start to suspect cholesterol's role in atherosclerosis?

The first clue that we have comes from 1910 with a paper by German chemist A. Windhaus reporting that his patients with atherosclerosis in autopsies, he found that their aortas were just chock full of cholesterol, like much more so than his patients who did not have the disease.

The second clue arrives a few years later, in 1913, when Russian experimental pathologist N.N.

Anichkow showed that when he fed rabbits basically pure cholesterol dissolved in sunflower oil, they quickly developed lesions in their blood vessels that looked a whole lot like human atherosclerosis.

The rabbits who were fed on a normal diet did not develop those same lesions.

Curious.

And he was inspired to do this not because of Windhouse's paper, but because of other previous work investigating whether too much protein was toxic and caused premature aging.

Interesting.

Yeah, which was kind of the idea at the time.

And so there were these studies where rabbits were fed on a super protein-rich diet, and the rabbits developed what looked like human atherosclerosis.

Hmm.

And so Anichkow wanted to know what it was.

Like, was it the protein?

What is it about the protein or that diet specifically that caused the lesions?

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