Gary Brecka

There is a new KRAS inhibitor molecule that is, for a subset of patients, appears to be miraculous.

Appears to be.

There is a new PD-1 inhibitor that has resulted in rectal cancer tumors melting away and disappearing right in front of the eyes of the physician over serial checks, what we call a complete pathologic response.

No chemo, no radiation, no surgery.

Wow.

How does the population get access to these?

So they have to have a certain type of gene mutation, microsatellite instability.

It might be 5% to 10% of individuals with a GI cancer that have this gene mutation.

Still, GI cancers are so prevalent, and they're absolutely exploding right now.

I mean, colorectal cancer is...

on a parabolic scale right now.

That's right.

It's doubled in people under 55 in the last two decades.

So we need new meaningful treatments that make sense.

We have to address root causes with diabetes.

There are some very promising new technology where islets are now infused and are not being rejected.

Into the pancreas.

Donor islets.

donor islets injected into a human with type 1 diabetes, and traditionally the body rejects these islets, just like a foreign organ.

And sometimes there's been protocols to try immunosuppression.