Ian Sample

speaker

2,123 appearances 29 recordings 3 series first heard Apr 2026 last heard 4d ago

Ian Sample’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 29 in all, peaking in Jun 2026 with 8.

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Science Weekly · Can a world-first gene therapy reverse ageing? · 16 Jul 2026 podcast

I mean, the big question, all trials are risky, but I talked to Paul about this. matched

So this is what he made of it. matched

Given all those risks that are inherent in this trial, I ask Paul, what do you think the chances of it working are? matched

If these guys see a success as in it's safe, but also probably hard to see from a phase one, but if they see a meaningful clinical improvement, if these people have their retinal cells become essentially younger and the disease abates, that is enormous. matched

It would be massive because that would say that this direction of research matched

is effective it's likely to work now doesn't mean you you suddenly have a an elixir for life on your hands right but matched

What this means is fundamental, okay, because at the moment we treat age-related diseases in isolation. matched

What this would suggest is that you can move towards this kind of goal of treating not those diseases individually, but treating ageing as a disease. matched

And so you keep ageing at bay, and so your cells are healthier, they're functioning more properly, and so those diseases do not... matched

manifest or certainly manifest a whole lot later depending on how much you can stem the tide right and that is obviously transformational for what medicine certainly what geriatric medicine means now okay come back to reality um this is a trial done in the eye and you can the eye is very self-contained if things go wrong at the worst they can take the eye out okay you can see what's happening as well in the eye if you're thinking about treatments across your body matched

How are you going to monitor it? matched

You know, you need to think about that very carefully. matched

And the damage you could cause could be so much greater, right? matched

So I think follow-up trials, the next trials that would be trying to look at different diseases would... matched

probably progress very slowly to get the permissions to do that. matched

And some of these things are not going to be easy. matched

You have to think about delivery. matched

How are you going to suddenly get these Yamanaka factors into particular places? matched

Sure, you can target the kidney, the liver, and isolated things. matched

But what if you... matched

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