James Deardorff
speaker
224 appearances
2 recordings
1 series
first heard Feb 2022
last heard Oct 2022
James Deardorff’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsNo recordings in the last 12 months.Older appearances are listed below; set an alert to hear about the next one.
Appearances
And it's very interesting looking at the literature on GI irritation because I think that's one of the common symptoms that we see when we're starting these medications.
And when you look at when these medications first started, there was a good case series in the New England Journal in 1996 that really documented some cases of severe esophagitis.
And a lot of it were people that were taking these medications inappropriately that you typically when on these oral medications, you want to take them in the morning on an empty stomach.
at least 30 minutes before a meal and then stay upright or standing for, for at least 30 minutes to reduce that risk of esophagitis or irritation.
And, and a lot of the times these case reports of esophagitis were happening in people that were taking them in the middle of the night, right.
or right before they went to bed, without water, things like that.
And so in the clinical trials, it does appear that the rates of GI irritation are pretty similar between placebo and dysphosphonate-treated groups.
I was interested to read that in
Yeah, there is this disconnect.
Like in the biggest trial with the lendronate, the fracture intervention trial,
about 30% in both groups had some GI irritation.
So it might just be the case that there's a lot of background GI complaints that people have that could be taking them inappropriately.
So there are definitely ways to minimize it, but we do see a lot of people reporting this and the GI irritations are the most common reason why people discontinue these medications.
then, yeah, the next, the other one, like you were saying with IV infusions, like zoledronic acid can cause this acute phase reaction, which is fever, headaches, muscle aches, fatigue.
And it can really happen in 20 to maybe 40% of people.
on our first dose.
And so, as you said before, with repeated doses, typically less, and you can pre-treat with Tylenol or ibuprofen to reduce these types of symptoms, but it can be a concern and can last for a few days.
And so, as Say was saying before, when you think about some of these immediate harms and burdens, we want to make sure that we're
treating people appropriately that can benefit from these medications.
Yeah.
Showing 121–140 of 224 · page 7 of 12
← Previous
Next →