James Deardorff
speaker
224 appearances
2 recordings
1 series
first heard Feb 2022
last heard Oct 2022
James Deardorff’s voice in public audio — every appearance, attributed to the second.
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And then we looked at clinical vertebral fractures as well.
Yeah, so overall, we identified kind of 10 clinical trials involving three different bisphosphonates, alendronate, resedronate, and zoledronic acid.
And so when did all the fancy statistical analysis with their survival curves.
And really what we found is that the time to benefit, to prevent one non real cheaper fracture among a hundred postmenopausal women with osteoporosis was 12.4 months.
So in other words, um, this meant that, uh, at an absolute risk reduction threshold of 0.01.
100 postmenopausal women with osteoporosis would need to be treated with a bisphosphonate for 12.4 months to prevent one nonvertebral fracture.
And so that's kind of the headline one.
We also looked at other outcomes like hip fracture.
And so hip fracture is a little bit more of a rare outcome.
And so
what we saw is that the time to benefit for hip fracture, it would take about 20.3 months treating 200 postmenopausal women to prevent one hip fracture.
So since it was a little bit rarer, would need more time and need to treat more women.
Yeah, I think, first of all, anything in medicine is not going to be like a slam dunk type thing, except when we're dealing with...
Like insulin and type 1 diabetes, it's pretty obvious.
And so when you first start to look at these numbers, like 1 in 100 for 12 months, sometimes it doesn't seem like that much of a benefit.
But when you're especially doing on a population level, the results can be pretty dramatic when we're dealing with preventing fractures that can have long-term morbidity and mortality.
And so...
When you think about other things that we do like colorectal cancer screening or mammography or even like statin therapy for preventing heart attacks and strokes, they all have pretty dramatic lengthy time.
So things like colonoscopy for cancer screening and somewhere in the range of 10 years.
Same thing with mammography as well for preventing breast cancer.
Showing 161–180 of 224 · page 9 of 12
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