James Zou
speaker
371 appearances
1 recordings
1 series
first heard Dec 2024
last heard Dec 2024
James Zou’s voice in public audio — every appearance, attributed to the second.
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Yeah, absolutely.
I th I do think that a lot of the time
For the virtual lab, it's actually, for example, like running alpha fold, right?
Because you need to run that across many different instances of proteins, candidate nanobodies, and that actually would take multiple days just to potentially just do one round of running alpha fold predictions across all of these different candidates.
And certainly I mean the biggest cost is still the experimental validations, right?
So
It took a few weeks to basically you have to uh synthesize these nanobodies.
So we use some basically CROs to make these proteins.
And then we have to actually do careful experiments to validate those proteins, their binding affinities.
And this is where we work very closely with our collaborators at the Chancellor Garbag Biohub, who are actually experts in doing these protein.
affinity assays then no so that's where there still needs to be a lot of human time involved.
That's right.
Yeah.
So I think in parallel we have also explored different collaborations with like different cloud labs where they would actually do like you have robots that can automate diff different experiments.
Those are also very exciting, especially for these more uh chemistry experiments and experiments like binding assays.
So I think that can be automated relatively well.
Where it's becomes still some more challenging as in assays that involve like cells and animals.
Those are more complex experiments are but I think the the automation will get there for these even cellular based assays.
So yeah, so I think it is quite interesting candidates, but we need to do a lot more experiments.
For example, we're currently doing some additional experiments where we have like the nano like the virtual lab now look at the first round of the experimental validation and see do they want to further modify or improve the nanobody in some way.
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