Jason Karlawish
speaker
1,378 appearances
5 recordings
1 series
first heard Feb 2021
last heard Dec 2023
Jason Karlawish’s voice in public audio — every appearance, attributed to the second.
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Appearances
Um, I think every geriatrician needs to know about TDP forty three disease.
It's probably the most common cause of dementia in that eight eighty plus crowd.
And uh oftentimes I think I in my own career was mislabeled as Alzheimer's.
Tell me what's very interesting.
Very well, late uh T D P forty three is a well described pathological ending in frontal temporal lobar disease that is the one of the primary pathologies in F T L D along with ubiquitin.
Um and it was in the last several years that autopsy studies showed that this eighty plus crowd of individuals with a densely amnestic form of uh uh dementia who
I'm one who labeled them as having Alzheimer's actually had T D P forty three disease as the driving pathology.
And the the characteristic hallmark is uh we don't have a
Uh we have emerging blood biomarkers for it, but the characteristic hallmark is an MRI imaging finding of very profound hippocampal atrophy below medial temporal lobes, excuse my highly clinical term, but really enormous atrophy in the medial temporal lobe area, um, with relative preservation of the cortex otherwise.
And we've been diagnosing it at Penn in days of old, I would have called the Malzheimers.
The question of course is if someone's got clear T D P disease but elevated amyloid 'cause the two.
There's
Now of course Medicare doesn't pay for them, but I think they should now start a demonstration project for Tau tests because we really, really, really I think that could help inform.
Bottom line, you have someone who meets criteria for late elevated amyloid negative Tau.
I would be very had to have a long conversation about the upsides and downsides of taking an anti amyloid agent.
I would be that's that's a that's an experiment in my view.
know.
I don't
if they were
I I I wonder if t it it's it's such an emergent diagnosis.
Showing 281–300 of 1,378 · page 15 of 69
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