Jason Karlawish

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1,378 appearances 5 recordings 1 series first heard Feb 2021 last heard Dec 2023

Jason Karlawish’s voice in public audio — every appearance, attributed to the second.

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One of the cases presented was someone with moderate dementia, elevated amyloid, obvious MRI changes consistent with T D P

uh history consistent with that as well.

And that individual was called as having Alzheimer's and T D P.

My reaction to that was

And oh negative tau, that was the other thing.

Negative tau.

So negative tau, elevated amyloid, TDP on MRI.

I'm like, well, no, wait a minute.

You really want to call that Alzheimer's just because there's elevated amyloid?

And again, I said, well, that's the biological definition.

That's the biological model.

Sure.

So we're gonna struggle on that.

Well here's what people really want.

It the biological definition is sort of is to some degree insider baseball.

No one wants to develop dementia.

And if you think about it, I the future I see for the field would be

It's about telling people what's your risk of getting dementia.

And we do that with cardiovascular disease with respect to what's my risk of getting a heart attack made in ten years.

We deal with osteoporosis, what's my risk of major osteoporotic fracture?

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