Jason Karlawish
speaker
1,378 appearances
5 recordings
1 series
first heard Feb 2021
last heard Dec 2023
Jason Karlawish’s voice in public audio — every appearance, attributed to the second.
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So these tr it didn't improve.
Um these are these are diseases as you know that are degenerative.
So the trajectory over time is loss of cognitive uh function and uh performance on uh activities of daily living, instrumental and basic.
So the measure here was a composite measure called the clinical dementia rating or CDR.
It's a measure that's used in research only.
I don't think it has ever or will ever be used in clinical practice.
And it's a composite measure that rates someone's performance on a sort of omnibus concepts of cognition, memory judgment, decision making, and then omnibus concepts of function like home and hobbies, uh personal care.
And uh that was the primary endpoint.
And as a very quirky way to look at the CDR, which is instead of the way it was designed, zero point five one two three, normal, very mild, mild, moderate, severe dementia, you can look at the sum of boxes, which is essentially taking the subscores that make up the the those z
zero point five one two three and treating them as subscores or the boxes, which is a cork of the instrument.
And so what they looked at was a difference in the CDR sum of boxes between decline in placebo versus the decline in drug group.
That was the primary and single primary endpoint for the study, which has become the primary endpoint for a lot of these studies.
points.
That's right.
The boxes range from zero to eighteen.
And and and that's the scale.
In this group of patients, the range of their CDR summa boxes was about zero to six with a mean median of three.
So that reiterates the question you asked, Eric Alex.
These were people with mild disease.
Their sum of boxes was stacked up at the mild stage, you know, uh of severity.
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