Jason Karlawish
speaker
1,378 appearances
5 recordings
1 series
first heard Feb 2021
last heard Dec 2023
Jason Karlawish’s voice in public audio — every appearance, attributed to the second.
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I mean it's a you know, so the label would say this drug is for the treatment of Alzheimer's disease and here's some other points depending on the person's self identified race and ethnicity about how you prescribe the drug.
I mean
I find that very problematic because behind race and ethnicity are a whole sort of cultural and social constructs.
So I'm not I I I'm still struggling with the in drug development
thinking about these issues with respect to understanding mechanism or prescribing.
But in terms of access to research and its benefits as well as its risks, y you know, I i it it it's it's a shame that our studies tend to simply reflect a s only a small slice of America, uh absolutely.
Yeah, so this is the fo this is the issue with forest plots, and it's kind of funny.
Uh well first of all, you get power issues.
Okay.
It's not
But secondly, forest plots
It's supposed to look at like overall am I seeing a trend that favors drug or overall am I seeing a trend that favors placebo or am I seeing things all over the place?
And the force plots are pretty compelling for a trend that favors drug.
Having said that, I'm the one that fixated on the ApoE because of the dose response aspect of that.
Zero, one, two copies of APOE4, you see across all the endpoints the same dose response reduction in benefit.
That doesn't lead me to say it doesn't work for people who have ApoE4.
It makes me concerned, and we need to understand more what is going on here, the APOE4 carriers.
are having s may not be as uh good responders.
But I wouldn't look at those force plots and say a woman from Europe
can't benefit from this drug because that's what the plots would suggest.
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