Jonathan Rosenthal

speaker

92 appearances 1 recordings 1 series first heard Jul 2026 last heard 30 Jul

Jonathan Rosenthal’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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Economist Podcasts · Working memory: the surprising decline of dementia · 30 Jul 2026 podcast

So that's the kind of no, we don't really know part of the answer.

But the yes part is that there is some really good data that's been coming out about what are the sorts of things that are associated with higher or lower rates of dementia.

And that is where the really promising research is going.

Part of what we, well, what I thought I knew about this is that the causes are at least partly genetic.

So we know there is a huge genetic component to risk for dementia.

And unfortunately, people can't change their genes.

They can change their behaviors.

Now, the particular gene that is associated with this is APOE4.

And the 25% of the population or so that have one copy of that APOE4 gene

have got a much higher risk of dementia.

I think it's about two to three times higher.

And a subset of them, about 2% of the population, have got two copies of that gene.

And the risk for them is about 10 to 15 times higher.

But again, those genes are very often just associations.

So a lot of people who've got those genes don't get dementia.

And a lot of people who don't have those genes do get dementia.

And that's where researchers have been looking into other factors.

And a lot of that is down to lifestyle.

What do you mean by lifestyle though?

Tell me about that.

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