Jonquilyn Hill

And I started noticing, you know, they all kind of have this kind of flat affect.

And none of them were depressed, but each one of them was saying things like, well, what's the point?

Maybe I don't even care about that job promotion.

Or, you know, yeah, I have kids.

Maybe it's the kids.

I don't know what it is, but I'm not even excited to go out with my friends.

And I thought about it and I was like, what's so different about these patients?

And these three in particular had been on GLP-1s.

And of course, you know, you can't make an inference based on three people, but it is what motivated me to start looking into more of the psychological effects, particularly around what we do and do not know about how GLP-1s affect dopamine and motivation seeking behavior.

They never put two and two together that this could be from the GLP-1s.

So you don't have a lot of reports on it because these three patients, they would have never thought about it.

It was more as me, an outside observer, thinking, wait a minute, what's this common thread?

They always make sense if it's something else, right?

So it's very hard to study.

The other thing is that there's a big difference between a person being depressed, which they have started looking into, does it affect suicidality and depression?

However, you have to think about depression in, yes, it can be that kind of apathy kind of feeling.

However, depression really implies a negative affect, right?

Like, I'm no good.

I don't feel like existing, right?

That's very different than a flatness.